Azithromycin belongs to the macrolide group of antibiotics. It interferes with bacterial protein synthesis by inhibiting the translation of mRNA.
It is used to treat the following conditions:
-
For the treatment of Chancroid (genital ulcer due to Haemophilus ducreyi).
-
For the treatment of bacterial exacerbation of Chronic obstructive pulmonary disease caused by:
-
Haemophilus influenzae
-
Moraxella catarrhalis
-
Streptococcus pneumoniae
-
-
For the prevention and treatment of Mycobacterium avium complex in patients with advanced HIV infection
-
For the treatment of acute otitis media caused by the following bacteria:
-
Haemophilus influenzae
-
M. catarrhalis
-
S. pneumoniae
-
-
For the treatment of community-acquired pneumonia caused by:
-
Chlamydophila pneumoniae
-
H. influenzae
-
Legionella pneumophila
-
M. catarrhalis
-
Mycoplasma pneumoniae
-
Streptococcus pneumoniae
-
-
Uncomplicated skin and soft tissue infections due to:
-
Staphylococcus aureus
-
Streptococcus pyogenes
-
Streptococcus agalactiae
-
-
As an alternative therapy for the treatment of tonsillitis or pharyngitis due to Streptococcus pyogenes.
-
For the treatment of Urethritis and cervicitis due to:
-
Chlamydia trachomatis
-
Neisseria gonorrhoeae
-
-
Off Label Uses of Azithromycin in Adults include:
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Acne vulgaris
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Babesiosis
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For the prevention of pulmonary exacerbations in patients with Bronchiectasis (non-cystic fibrosis)
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Bronchiolitis obliterans syndrome (in patients with lung transplant)
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Campylobacter infection
-
Cat scratch disease
-
For perioperative prophylaxis during Cesarean delivery
-
Chlamydia trachomatis infection of the pharynx
-
For expedited partner therapy of Chlamydia trachomatis infection
-
Cholera
-
Prevention of pulmonary exacerbations in patients with Chronic obstructive pulmonary disease
-
Cystic fibrosis
-
Prophylaxis of endocarditis (prior to a dental or invasive respiratory tract procedure)
-
Disseminated gonococcal infection (including gonococcal arthritis, arthritis-dermatitis syndrome, meningitis, and endocarditis)
-
expedited partner therapy for Gonococcal infection
-
Uncomplicated Gonococcal infection of the rectum, pharynx, and conjunctiva
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Granuloma inguinale
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Lyme disease
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Mycobacterium abscessus infection
-
Mycoplasma genitalium
-
Pertussis
-
For the prophylaxis of Sexually transmitted infections in individuals following a sexual assault
-
Shigella infection
-
Surgical prophylaxis in patients following uterine evacuation (after abortion or pregnancy loss)
-
Primary and Secondary Syphilis
-
Empiric treatment of Travelers' diarrhea
-
Azithromycin for the treatment of COVID-19 infection:
- Azithromycin has recently been studied in patients with coronavirus infection along with the antimalarial drug hydroxychloroquine.
- The author of the study suggested that the use of azithromycin in combination with hydroxychloroquine resulted in a significant reduction of positive cases after 6 days (25% vs 90%) [Ref].
- Since both Azithromycin and hydroxychloroquine can result in QTc prolongation, this combination should be used with extreme caution.
- Furthermore, more studies are needed before they are considered effective and safe.
Azithromycin Dose in Adults
Dose for Off-label use in the treatment of moderate to severe inflammatory Acne vulgaris as an adjunct to topical acne therapy:
- Dosing regimens varied in different clinical trials.
- Regimen 1:
- 500 mg orally once a day for 4 consecutive days per month for 3 consecutive months or
- Regimen 2:
- 500 mg orally once a day for 3 days in the first week, followed by 500 mg once a week until week 10 or
- Regimen 3:
- 500 mg orally once a day for 3 consecutive days each week in month 1, followed by 500 mg once a day for 2 consecutive days each week in month 2, then 500 mg once a day for 1 day each week in month 3.
- Regimen 1:
Dose for Off-label use in the treatment of Babesiosis:
-
Mild to moderate disease:
- 500 mg orally on day 1, followed by 250 mg once a day in combination with atovaquone for 7 - 10 days in immunocompetent patients.
-
Severe disease:
- 500 mg intravenous daily in combination with atovaquone for 7 - 10 days.
Dose for Off-label use in the treatment and prevention of pulmonary exacerbation of Bronchiectasis (non-cystic fibrosis):
- 500 mg orally 3 times a week or 250 mg once a day.
- All patients should be screened for non-tuberculous mycobacterial infection.
Dose for Off-label use in the treatment of Bronchiolitis obliterans syndrome in recipients of lung transplant:
- 250 mg orally once a day for 5 days, followed by 250 mg 3 times a week for at least a 3 months.
- Some experts continue it indefinitely regardless of the response to therapy.
Dose for Off-label use in the treatment of Cat scratch disease:
- 500 mg orally as a single dose, then 250 mg once a day for 4 additional days.
Dose in the perioperative prophylaxis of Cesarean delivery:
- 500 mg intravenous as a single dose one hour before a surgical incision in combination with standard preoperative antibiotics.
Dose in the treatment of Chronic obstructive pulmonary disease:
-
Treatment of Bacterial exacerbation:
- 500 mg orally on day 1, followed by 250 mg once a day for a total of 5 days or
- 500 mg orally once daily for three days.
-
Prevention of exacerbations as off-label use:
- 250 - 500 mg orally 3 times a week or
- 250 mg orally once a day
Dose as Off label use in the treatment of Cystic fibrosis as an anti-inflammatory drug:
- 250 mg (individuals with a weight of less than 40 kg) or 500 mg (patients weighing more than 40 kgs) orally 3 times a week or
- 250 mg once a day.
Dose as off Label use in the treatment of infectious Diarrhea:
-
Campylobacter infection:
- 1 gm orally as a single dose (may administer 500 mg/day for 2 more days in symptomatic patients or
- 500 mg orally once daily for three days
- HIV infected patients should receive 500 mg once ay for 5 days.
-
As an alternative agent in Cholera:
- 1 gm orally as a single dose
-
Shigella infection:
- 500 mg orally once daily for three days
- HIV patients and those with Shigella dysenteriae type 1 infection should be given the drug for 5 days.
-
Empiric treatment of Travelers' diarrhea:
- 1 gm orally as a single dose (symptomatic patients may be advised the drug for 2 more days at a dose of 500 mg per day) or
- 500 mg orally once daily for three days (it is considered the preferred regimen in febrile patients).
Off-label use for the prophylaxis of endocarditis prior to a dental or invasive respiratory procedure (as an alternative agent for penicillin-allergic patients):
- 500 mg orally 30 - 60 minutes prior to the procedure.
Dose as Off-label use in the treatment of Lyme disease (erythema migrans or borrelial lymphocytoma) as an alternative agent:
-
- 500 mg orally once a day for 7 - 10 days.
Dose in the treatment of non-tuberculosis Mycobacterial infection:
-
Mycobacterium avium complex (MAC) infection:
- Disseminated disease in HIV-infected patients:
-
Treatment of MAC:
- 500 - 600 mg orally once a day in combination therapy regimen
-
Primary prophylaxis (patients with CD4 count <50 cells/mm³ ):
- 1,200 mg orally once a week (preferred) or
- 600 mg orally twice a week
- Prophylaxis may be discontinued when CD4 count is greater than 100 cells/mm³ for 3 months or more in response to antiretroviral therapy (ART).
-
Secondary prophylaxis:
- 500 - 600 mg orally once a day in combination with other appropriate regimens
- It may be discontinued when the patient has completed 12 months of therapy, with no features of MAC disease, and has a CD4 count of more than 100 cells/mm³ in response to ART for a sustained period (usually more than 6 months)
-
- Disseminated disease in HIV-infected patients:
Off label use in the treatment of nodular or bronchiectatic pulmonary disease:
- 500 - 600 mg orally 3 times a week until the patient is culture-negative on therapy for one year or more (in combination with other appropriate therapy)
Off label use in the treatment of severe nodular/ bronchiectatic or cavitary Pulmonary disease:
- 250 - 500 mg orally once a day (in combination with other appropriate therapy)
- The treatment should be continued until the patient is culture-negative on therapy for 1 year or more.
Dose as Off-label use in patients with cystic fibrosis:
- 250 - 500 mg orally once a day (in combination with other appropriate therapy) until the patient is culture negative for one year or more.
- Patients with cystic fibrosis should not be advised intermittent (3 times a day) therapy.
Dose for Mycobacterium abscessus infection (off-label use):
-
Pulmonary, skin, soft tissue, or bone infection:
- 250 - 500 mg orally once a day (in combination with other appropriate therapy)
- For the treatment of pulmonary and bone infections, the treatment should be continued for 6 - 12 months, and for 4 months or more in patients with skin and soft tissue infections.
Off Label use in the treatment of Pertussis:
- 500 mg orally on day 1, followed by 250 mg once a day for a total of 5 days.
Dose in the treatment of community-acquired Pneumonia:
-
Outpatient management:
- 500 mg orally on day 1, followed by 250 mg once a day for 4 days or
- 500 mg orally once daily for three days.
-
Inpatient management:
- 500 mg orally or intravenously once a day for a minimum of 3 days.
Dose in the treatment of Sexually transmitted infections:
-
Empiric therapy for Cervicitis:
- 1 gm orally as a single dose in combination with ceftriaxone.
-
Chancroid (caused by Haemophilus ducreyi ):
- 1 gm orally as a single dose.
-
Chlamydia trachomatis infection of the urethra, cervix, or pharynx (as off-label use:
- 1 gm orally as a single dose
-
Chlamydia trachomatis infection for the treatment of expedited partner (off-label use):
- 1 gm orally as a single dose.
-
Disseminated Gonococcal Infection ( including arthritis, arthritis-dermatitis, meningitis, and endocarditis) as off label use:
- 1 gm orally as a single dose in combination with ceftriaxone.
-
Gonococcal infection for expedited partner therapy (as off- label use):
- 1 gm orally as a single dose in combination with cefixime.
-
Uncomplicated gonococcal infection (infection of the cervix, urethra, rectum, pharynx, or conjunctiva):
-
Dual-therapy regimen (as off-label use):
- 1 gm orally as a single dose in combination with ceftriaxone
-
Patients with allergy to cephalosporins (as off-label use):
- 2 gms as a single dose in combination with gemifloxacin or intramuscular gentamicin.
-
-
Granuloma inguinale (donovanosis) as off-label use:
- 1 gm orally once a week or 500 mg once a day for 3 weeks or more and until the lesions have healed.
- Gentamicin may be added to the therapy if the lesions are not healed within one week.
-
Mycoplasma genitalium (as off-label use):
- 1 g orally as a single dose or
- 500 mg orally on day 1, followed by 250 mg once a day for 4 days.
-
Prophylaxis against sexually transmitted infections following sexual assault (as off-label use):
- 1 gm as a single dose in combination with ceftriaxone and metronidazole or tinidazole.
-
Primary and Secondary Syphilis in penicillin-allergic patients (off-label use):
- 2 gms orally as a single dose.
-
For the empiric therapy of Urethritis:
- 1 gm orally as a single dose in combination with ceftriaxone.
Dose in the treatment of group A streptococcal pharyngitis as an alternative agent for the severely penicillin-allergic patients:
- 500 mg orally on day 1, followed by 250 mg once a day for 4 days or
- 500 mg orally once daily for three days.
Off label use for the surgical prophylaxis of uterine evacuation in patients with abortion or a pregnancy loss:
- 500 mg orally as a single dose one hour prior to the procedure.
Dose in the treatment of drug-resistant Typhoid fever:
- 1 gm orally as a single dose, followed by 500 mg once a day for 7 - 10 days in combination with meropenem.
Azithromycin dose in the treatment of coronavirus infection:
- 500 mg twice daily for five days along with hydroxychloroquine 400 mg twice daily on day one then 200 mg twice daily for four days.
Azithromycin Dose in Childrens
General dosing for susceptible infections:
-
Mild to moderate infection:
- 5 - 12 mg/kg/dose orally ( usually it is administered as 10 - 12 mg/kg/dose on day 1 followed by 5 - 6 mg/kg once a day.
- The usual maximum dose for the total course is 1,500 - 2,000 mg.
-
Serious infection:
- 10 mg/kg intravenous once a day to a maximum dose of 500 mg/dose.
Dose in the treatment of Babesiosis:
- 10 mg/kg orally once on day 1 to a maximum dose of 500 mg/dose), then 5 mg/kg once a day on days 2 - 10 (maximum dose of 250 mg/dose) in combination with atovaquone.
Dose in the treatment of Bartonellosis (Cat scratch disease) with extensive lymphadenopathy in HIV-negative patients:
-
Infants, Children, and Adolescents weighing 45 kgs or less:
- 10 mg/kg orally once on day 1 to a maximum dose of 500 mg/dose, followed by 5 mg/kg once a day for 4 days to a maximum dose of 250 mg/dose.
-
Children and Adolescents weighing more than 45 kgs:
- 500 mg orally as a single dose on day 1, then 250 mg once a day for 4 days.
Cutaneous bacillary angiomatosis (caused by B. henselae or B. quintana) in HIV-Positive patients:
- 5 - 12 mg/kg orally once a day to a maximum dose of 600 mg/dose for 3 months.
Dose in the treatment of Chancroid:
-
Children weighing less than 45 kgs:
- 20 mg/kg orally as a single dose (to a maximum dose of 1,000 mg/dose)
-
Children weighing more than 45 kgs:
- 1,000 mg orally as a single dose
Dose in the treatment of Chlamydial infections:
-
Cervicitis and urethritis:
- Children and Adolescents weighing more than 45 kgs:
- 1,000 mg orally as a single dose
-
Conjunctivitis (infants):
- 20 mg/kg orally or intravenous once a day for 3 days.
-
Community-acquired Pneumonia:
-
Mild infection or step-down therapy:
- 10 mg/kg orally once on day 1 to a maximum dose of 500 mg/dose, followed by 5 mg/kg once a day for 4 days to a maximum dose of 250 mg/dose.
-
Severe infection:
- 10 mg/ kg intravenous once a day for at least 2 days.
- Switch to oral azithromycin as a single daily dose of 5 mg/kg (maximum 500 mg/dose) to complete the course.
-
-
For the treatment of patients with Cystic fibrosis to improve lung function and reduce the frequency of exacerbations:
-
Children older than 6 years and Adolescents:
-
18 - 35.9 kg:
- 250 mg orally three times a week (Monday, Wednesday, Friday)
-
More than 36 kgs:
- 500 mg orally three times a week (Monday, Wednesday, Friday)
-
- Children and Adolescents weighing more than 45 kgs:
Dose in the treatment of infectious Diarrhea:
-
Campylobacter:
- 10 mg/kg orally once a day for 3 days to a maximum dose of 500 mg/dose
-
Shigellosis:
-
AAP Recommendation:
- 12 mg/kg orally once on day 1 to a maximum dose of 500 mg/dose, followed by 6 mg/kg once a day for 4 days to a maximum dose of 250 mg/dose.
-
Alternate dosing:
- 10 mg/kg orally once daily for three days
- WHO Guidelines recommend up to 20 mg/kg/dose.
-
Use in the prophylaxis Endocarditis:
- 15 mg/kg/dose orally 30 - 60 minutes prior to the procedure to a maximum dose of 500 mg/dose.
Use in the treatment of uncomplicated gonococcal cervicitis, urethritis, and anorectal disease:
-
Children less than 45 kgs:
- 20 mg/kg orally as a single dose to a maximum dose of 1,000 mg/dose.
-
Children older than 8 years and weighing more than 45 kgs:
- 1,000 mg orally as a single dose.
Use in the treatment of Group A streptococcal tonsillopharyngitis:
-
Manufacturer's labeling and AHA recommendations:
- 2 mg/kg/dose orally once a day for 5 days to a maximum dose of 500 mg/dose.
-
Alternate dosing (IDSA recommendations):
- 12 mg/kg orally to a maximum dose of 500 mg/dose on day 1 followed by 6 mg/kg/dose to a maximum dose of 250 mg/dose once a day for 4 days.
-
Three-day regimen:
- 20 mg/kg/dose orally once a day for 3 days to a maximum dose of 1,000 mg/dose.
Use for the prophylaxis of Meningococcal disease in high-risk contacts:
- 10 mg/kg orally as a single dose to a maximum dose of 500 mg/dose
Dose in the treatment of Mycobacterium avium complex (MAC) infection in HIV-positive patients:
- Infants and Children:
-
Treatment of MAC infection:
- 10 - 12 mg/kg orally once a day in combination with ethambutol (with or without rifabutin) to a maximum dose of 500 mg/dose for at least 12 months.
-
Primary prevention of first episode:
- The preferred regimen is administered as 20 mg/kg once a week to a maximum dose of 1,200 mg/dose) or
- alternatively 5 mg/kg once a day to a maximum dose of 250 mg/dose.
-
Secondary prevention of recurring episodes:
- 5 mg/kg once a day in combination with ethambutol (with or without rifabutin) to a maximum dose of 250 mg/dose.
-
- Adolescents:
-
Treatment:
-
500 - 600 mg orally once a day in combination with ethambutol
-
-
Primary prophylaxis:
-
1,200 mg orally once a week or
-
alternatively, 600 mg two times a week
-
-
Secondary prophylaxis:
-
500 - 600 mg once a day in combination with ethambutol
-
-
Use in the treatment of acute Otitis media (Should not be given routinely because of resistance):
- Infants older than 6 months, Children, and Adolescents:
-
Single-dose regimen:
-
30 mg/kg orally as a single dose to a maximum dose of 1,500 mg/dose.
-
-
Three-day regimen:
-
10 mg/kg orally once a day for 3 days to a maximum dose of 500 mg/dose
-
-
Five-day regimen:
-
10 mg/kg orally once on day 1 to a maximum dose of 500 mg/dose, followed by 5 mg/kg to a maximum dose of 250 mg/dose once a day for 4 days.
-
-
Dose in the treatment of peritonitis in patients on peritoneal dialysis and for the prophylaxis for patients receiving peritoneal dialysis prior to a dental procedure:
- 15 mg/kg orally administered 30 - 60 minutes prior to a dental procedure to a maximum dose of 500 mg/dose.
Dose in the treatment of Pertussis:
-
Infants 1 - 5 months:
-
10 mg/kg/dose once a day for 5 days
-
-
Infants older than 6 months, Children, and Adolescents:
- 10 mg/kg once on day 1 to a maximum dose of 500 mg/dose, followed by 5 mg/kg once a day for 4 days to a maximum dose of 250 mg/dose.
Dose in the treatment of community-acquired Pneumonia (excluding mycoplasma pneumonia and chlamydial infections):
-
Immediate release:
-
Infants older than 3 months, Children, and Adolescents:
- 10 mg/kg orally once on day 1 to a maximum dose of 500 mg/dose, followed by 5 mg/kg to a maximum dose of 250 mg/dose once a day for 4 days.
-
-
Extended-release oral suspension:
-
Infants older than 6 months, Children, and Adolescents:
- 60 mg/kg orally as a single dose to a maximum dose of 2,000 mg/dose
-
Infants older than 3 months, Children, and Adolescents:
- 10 mg/kg intravenous once a day for at least 2 days.
- The intravenous therapy should be followed by oral treatment with a single daily dose of 5 mg/kg (maximum dose of 500 mg/dose) to complete a 5-day course of therapy.
-
Use in the treatment of community-acquired pneumonia due to mycoplasma pneumonia or chlamydial infection:
- Infants older than 3 months, Children, and Adolescents:
-
Mild infection or step-down therapy:
- 10 mg/kg orally once on day 1 to a maximum dose of 500 mg/dose followed by 5 mg/kg once a day for 4 days to a maximum dose of 250 mg/dose.
-
Severe infection:
- 10 mg/kg intravenous once a day for at least 2 days to a maximum dose of 500 mg/dose.
- Switch to the oral route with a single daily dose of 5 mg/kg (maximum of 250 mg/dose) to complete the course
-
Dose in the treatment of bacterial Rhinosinusitis:
- Infants older than 6 months, Children, and Adolescents:
- 10 mg/kg orally once a day for 3 days to a maximum dose of 500 mg/dose.
Dose in the prophylaxis of Sexual victimization:
-
Children less than 45 kgs:
- 20 mg/kg as a single dose in combination with cefixime or ceftriaxone
-
Children older than 45 kg and Adolescents:
- 1,000 mg as a single dose in combination with cefixime or ceftriaxone
Dose in the treatment and prevention of Toxoplasmosis in HIV-positive patients:
- 900 - 1,200 mg orally once a day in combination with pyrimethamine and leucovorin for 6 weeks (or longer if an extensive disease or incomplete response at 6 weeks).
Pregnancy Risk Factor B
- However, Azithromycin can cross the placental boundary, but adverse fetal outcomes were not observed in animal studies.
- It is recommended to treat several infections during pregnancy, including:
- Chlamydia
- Gonococcal Infections
- Mycobacterium avium complex (MAC)
Use of azithromycin while breastfeeding
- It is excreted from breast milk.
- Maternal macrolides can cause nausea, vomiting, diarrhea, rash and somnolence in nursing infants.
- Breastmilk can also contain antibiotics that may cause non-dose-related changes in the bowel flora. Monitor infants for signs and symptoms of gastrointestinal problems.
- The data are inconsistent, but infantile hypertrophic Pyloric Steenisis has been linked to maternal use of macrolides during the first two weeks.
- It is recommended to be used in breastfeeding women according to the manufacturer's instructions.
- According to the CDC's Sexually Transmitted Diseases Treatment Guidelines it is recommended for treatment of granuloma Inguinale as well as as an alternative agent to treat lymphogranuloma venereum among lactating women.
Azithromycin Dose in Renal Disease:
- Adjustment in the dose has not been provided by the manufacturer in patients with renal disease.
- Patients with a CrCl of less than 10 ml/minute should be advised the drug with caution.
Azithromycin Dose in Liver Disease:
- Adjustment in the dose has not been provided by the manufacturer in patients with liver disease.
- However, since it is hepatically eliminated, it should be used with caution in patients with liver disease.
- Patients who develop symptoms of hepatic impairment should immediately discontinue therapy.
Common Side Effects of Azithromycin Include:
-
Gastrointestinal:
- Loose stools
- Vomiting
- Diarrhea
Less Common Side Effects of Azithromycin Include:
-
Cardiovascular:
- Chest Pain
- Palpitations
-
Central Nervous System:
- Dizziness
- Drowsiness
- Fatigue
- Headache
- Vertigo
-
Dermatologic:
- Skin Rash
- Dermatitis
- Pruritus
- Skin Photosensitivity
-
Endocrine & Metabolic:
- Increased Lactate Dehydrogenase
- Increased Gammaglutamyl Transferase
- Increased Serum Potassium
- Decreased Serum Bicarbonate
- Decreased Serum Glucose
-
Gastrointestinal:
- Abdominal Pain
- Anorexia
- Dysgeusia
- Dyspepsia
- Flatulence
- Gastritis
- Melena
- Mucositis
- Oral Candidiasis
-
Genitourinary:
- Vaginitis
- Genital Candidiasis
-
Hematologic & Oncologic:
- Decrease In Absolute Neutrophil Count
- Decreased Hematocrit
- Decreased Hemoglobin
- Increased Neutrophils
- Thrombocythemia
- Change In Neutrophil Count
- Eosinophilia
- Lymphocytopenia
-
Hepatic:
- Increased Serum ALT
- Increased Serum AST
- Increased Serum Bilirubin
- Cholestatic Jaundice
-
Local:
- Pain At Injection Site
- Local Inflammation
-
Neuromuscular & Skeletal:
- Increased Creatine Phosphokinase
-
Renal:
- Increased Serum Creatinine
- Increased Blood Urea Nitrogen
- Nephritis
-
Respiratory:
- Bronchospasm
-
Miscellaneous:
- Fever
Contraindication to Azithromycin Include:
- Allergy reactions to azithromycin, Erythromycin, Other Macrolide Antibiotics, and any component of the formulation
- Histories of hepatic dysfunction and cholestasis following prior azithromycin treatment.
Warnings and Precautions
-
Hypersensitivity reactions
- Allergic reactions including anaphylaxis, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis and drug reaction with eosinophilia and systemic symptoms [DRESS]) may occur that may be fatal at times.
-
Modified cardiac conduction
- Patients with QTc prolongation, ventricular arrhythmias, or torsades-de-pointes should avoid Macrolides, especially erythromycin.
- Patients with prolonged QT intervals, congenital long QT Syndrome, history of torsades, bradyarrhythmias and uncorrected hypomagnesemia/hypokalemia should avoid it.
-
Cardiac risk
- Azithromycin is associated with a higher risk of developing a heart attack than amoxicillin or ciprofloxacin.
-
Superinfection
- Extended use of azithromycin for more than two months has been linked to fungal and bacterial superinfections, including Clostridium difficile.
-
Gonorrhea, syphilis
- Before initiating any treatment, it is important to perform appropriate culture and susceptibility testing.
- This may be necessary because it can mask or delay symptoms such as syphilis or gonorrhea.
-
Hepatic impairment
- Preexisting liver disease, hepatic impairment, hepatic necrosis and hepatic failure should be avoided.
- Patients with symptoms of liver disease such as nausea, vomiting and colic should stop taking medication immediately.
-
Myasthenia gravis:
- It can worsen myasthenia gravis symptoms.
-
Renal impairment
- Patients with kidney disease should be cautious with this drug, particularly if their GFR is less than 10ml/minute.
Monitoring Parameters:
- Monitor CBC with differential counts and Liver function tests.
How to administer Azithromycin?
-
Intravenous administration:
- It should not be injected as a bolus and should not be administered via the intramuscular route.
- Infuse over one hour at a concentration of 2 mg/ml or over three hours (1 mg/ml infusion). Not for Intramuscular or Intravenous bolus administration.
-
Oral administration:
- The immediate-release formulations may be taken without regard to meals.
- The extended-release formulations should be taken via empty stomach (at least one hour before or two hours after a meal)
Mechanism of action of Azithromycin:
- It binds to the 50s subunit of bacterial ribosomal inhibiting mRNA translation.
- It interferes with the bacterial protein synthesis.
It is growing rapidly absorbed It is found in the gastrointestinal tract. It is widely distributed.
distributed In the tissues, including the skin, lungs and tonsils.
The CSF penetration is very poor. 7 to 51% of the drug are protein bound It is then metabolized by liver to inactive compounds.
BioavailabilityThe extended-release formulation has a 28% to 43% concentration, while the immediate-release formulations have a 34% to 52% concentration.
Half-life elimination Zithromycin is effective in children for 54.5 hours, adults for 68-72 hours with the immediate-release formulation and 59 hours with the extended-release formulation.
Time to get there peak serum concentration It takes 2 - 3 hours to prepare the immediate-release formulation, while the extended-release formulation takes 3 - 5 hours.
It is excreted via the bile (via bile) as an unchanged drug
Azithromycin international brands:
- Ajustin
- Aratro
- Atizor
- ATM-200
- Aza-250
- Aza-500
- Azadose
- Azas
- Azath
- Azatril
- Azax
- Azbact
- Azce
- Azee
- Azeemycin
- Azenil
- Azent
- Azi-500
- Azibact
- Azibiot
- Azicine
- Azilide-250
- Azilide-500
- Azimac
- Azimacron
- Azimax
- Azimed
- Azin
- Azinobin
- Aziphar
- Aziraz
- Azirocin
- Azith
- Azithral
- Azithrin
- Azithro
- ACT Azithromycin
- AG-Azithromycin
- APO-Azithromycin
- APO-Azithromycin Z
- DOM-Azithromycin
- GD-Azithromycin
- GEN-Azithromycin
- JAMP-Azithromycin
- Mar-Azithromycin
- MYLAN-Azithromycin
- Novo-Azithromycin Pediatric
- PHL-Azithromycin
- PMS-Azithromycin
- PRO-Azithromycin
- RATIO-Azithromycin
- RIntravenousA-Azithromycin
- SANDOZ Azithromycin
- TEVA-Azithromycin
- Zithromax
- Zmax SR
- Azithrom
- Azitops
- Azitrex
- Azitrix
- Azitrocin
- Azitromax
- Azitrox
- Aziwok
- Azm
- Azo-500
- Azomycin
- Azomyne
- Azox
- Azro
- Azromax
- Aztrin
- Azyth
- Azytro
- Binozyt
- Clindal AZ
- Cronopen
- Decantin
- Enaz DS
- Floctil
- Glazi
- Imexa
- Inedol
- Jazit
- Koptin
- Macromax
- Macrozit
- Maxmor
- Mazit
- Meithromax
- Neazi
- OD Mac
- Odazyth
- Onzet
- Ormax
- Shepherd
- Thromaxin
- Tromix
- Ultreon
- Unizithrin
- Uzet
- Vinzam
- Weihong
- Wiltrozin
- Xithrone
- Zaha-250
- Zaret
- Zarom
- Zedbac
- Zedd
- Zemax
- Zenith
- Zeto
- Zetron
- Zicho
- Zimac
- Zimax
- Zimericina
- Zinfect
- Zistic
- Zithromac SR
- Zithromax
- Zithromax Intravenous
- Zithrotel
- Zithrox
- Zitrim
- Zitrocin
- Zitrolin
- Zitromax
- Zmax
- Zmax One Dose
- Zocin
- Zomax
- Zymed
- Zynomax
- Zyomycin
- Zythrocin
Azithromycin Brands in Pakistan
|
Azithromycin [Inj 500 Mg] |
|
| Acro | S.J. & G. Fazul Ellahie (Pvt) Ltd. |
| Mezomed | Mediate Pharmaceuticals (Pvt) Ltd |
| Nintramuscularoconil | Vision 2000 Plus |
| Zeecin | Wilshire Laboratories (Pvt) Ltd. |
| Zezot | Bosch Pharmaceuticals (Pvt) Ltd. |
| Zithrax | Biocare Pharmaceutical |
|
Azithromycin [Inf 500 Mg] |
|
| Azintramuscularycin | Mediceena Pharma (Pvt) Ltd. |
|
Azithromycin [Susp 50 Mg/5ml] |
|
| Rasmic | Rasco Pharma |
|
Azithromycin [Susp 100 Mg/5ml] |
|
| Megazith | Crest Pharmaceuticals |
|
Azithromycin [Susp 125 Mg/5ml] |
|
| Reclocin | Zinta Pharmaceuticals Industries |
|
Azithromycin [Susp 200 Mg/5ml] |
|
| Acasia | Nexpharm |
| Acro | S.J. & G. Fazul Ellahie (Pvt) Ltd. |
| Alide | Pharmix Laboratories (Printravenousate) Lintramuscularited. |
| Artiwin | Wns Field Pharmaceuticals |
| Athofix | The Schazoo Laboratories Ltd. |
| Axalina | Alina Combine Pharmaceuticals (Pvt) Ltd. |
| Azicure | Semos Pharmaceuticals (Pvt) Ltd. |
| Azidose | Shaheen Pharmaceuticals |
| Azilite | Webros Pharmaceuticals |
| Azintramuscularycin | Mediceena Pharma (Pvt) Ltd. |
| Azirolide | P.D.H. Pharmaceuticals (Pvt) Ltd. |
| Azirom | Macquins International |
| Aziromycin | Nawan Laboratories (Pvt) Ltd. |
| Azit | Raazee Theraputics (Pvt) Ltd. |
| Azita | Tg Pharma |
| Azitek Suspension | Hygeia Pharmaceuticals |
| Azithro | Goodman Laboratories |
| Azithrocin | Bex Pharma (Pvt) Ltd. |
| Azithrosaf | Saaaf Pharmaceuticals |
| Azintravenousid | Multinational Buisness Link |
| Azo | Ethical Laboratories (Pvt) Ltd. |
| Azobrain | Winbrain Research Laboratories |
| Azocam | Chas. A. Mendoza |
| Azocin | Trison Research Laboratories (Pvt) Ltd |
| Azogil | Glitz Pharma |
| Azolib | Stalwart Pharmaceuticals (Pvt) Ltd |
| Azom | Lotus Pharmaceuticals (Pvt) Ltd |
| Azomax | Novartis Pharma (Pak) Ltd |
| Azomax | Novartis Pharma (Pak) Ltd |
| Azomer | Miracle Pharmaceuticals(Pvt) Ltd |
| Azores | Saydon Pharmaceutical Industries (Pvt) Ltd. |
| Azorox | Caylex Pharmaceuticals (Pvt) Ltd. |
| Azotine | Nintramuscularrall Laboratories |
| Azoxin | Flow Pharmaceuticals (Pvt) Ltd. |
| Azpar | Zesion Pharmaceutical (Pvt) Ltd |
| Azrocin | Obsons Pharmaceuticals |
| Azrowin | Wns Field Pharmaceuticals |
| Bactizith | W.Woodward Pakistan (Pvt) Ltd. |
| Biozit | Leama Chemi Pharma (Pvt.) Ltd. |
| Chemzee | Ideal Pharmaceutical Industries |
| Exonex | Pharma Health Pakistan (Pvt) Ltd |
| Ezill | Dr. Raza Pharma (Printravenousate) Lintramuscularited |
| Ezonex | Mass Pharma (Printravenousate) Lintramuscularited |
| Fazi | Farm Aid Group Pak Ltd. |
| Fenzy | Noa Hemis Pharmaceuticals |
| Geozit | Geofman Pharmaceuticals |
| Hyzitek | Hygeia Pharmaceuticals |
| Kraze | Medicaids Pakistan (Pvt) Ltd. |
| Legzith | Legacy Pharmaceuticals |
| Maczin | Mcolson Research Laboratories |
| Mezomed | Mediate Pharmaceuticals (Pvt) Ltd |
| Mynex | Nexus Pharma (Pvt) Ltd |
| Od-3 | Adamjee Pharmaceuticals (Pvt) Ltd. |
| Orzit | Seatle Pharma Pakistan (Pvt) Ltd. |
| Plazo | Platinum Pharmaceuticals (Pvt.) Ltd. |
| Ramoff | Valor Pharmaceuticals |
| Rasthro | Rasco Pharma |
| Resque | Standpharm Pakistan (Pvt) Ltd. |
| Romy | Fozan Pharmaceuticals Industriers (Pvt) Ltd |
| Romycin | Surge Laboratories (Pvt) Ltd. |
| Rothin | Rakaposhi Pharmaceutical (Pvt) Ltd. |
| Servaz | Kaizen Pharmaceuticals Pvt Ltd. |
| Spell | Tagma Pharma (Pvt) Ltd. |
| Syzcin | Sayyed Pharmaceuticals |
| Throb | Bio Labs (Pvt) Ltd. |
| Welromycin | Welwrd Pharmaceuticals |
| Xabest | Everest Pharmaceuticals |
| Z-Mac | Opal Laboratories (Pvt) Ltd. |
| Zatrocin | Pearl Pharmaceuticals |
| Zeecin | Wilshire Laboratories (Pvt) Ltd. |
| Zemark | Unintramuscularark Pharmaceuticals |
| Zetro | Getz Pharma Pakistan (Pvt) Ltd. |
| Zewin | Orta Labs. (Pvt) Ltd. |
| Zezot | Bosch Pharmaceuticals (Pvt) Ltd. |
| Zicure | Medicaids Pakistan (Pvt) Ltd. |
| Zirocin | Trigon Pharmaceuticals Pakistan (Pvt) Ltd. |
| Zitamax (Zithromax) | Pfizer Laboratories Ltd. |
| Zithin Suspension | Panacea Pharmaceuticals |
| Zithosintramuscular | Sintramuscularz Pharmaceuticals |
| Zithrofame | Lloyds Pharmaceuticals |
| Zithromed | Medicraft Pharmaceuticals (Pvt) Ltd. |
| Zithrovel | Well & Well Pharma (Pvt) Ltd |
| Zomax | Helix Pharma (Printravenousate) Lintramuscularited |
| Zomax | Helix Pharma (Printravenousate) Lintramuscularited |
| Zorix | Lahore Chemical & Pharmaceutical Works (Pvt) Ltd |
| Zygrel | Searle Pakistan (Pvt.) Ltd. |
| Zyson Suspension | British Pharmaceuticals Ltd |
|
Azithromycin [Susp 250 Mg/5ml] |
|
| Azicin | Acme Laboratories Pakistan (Pvt) Ltd. |
| Azocure | Orta Labs. (Pvt) Ltd. |
| Azorox | Jawa Pharmaceuticals(Pvt) Ltd. |
|
Azithromycin [Tabs 250 Mg] |
|
| Aptintramuscularac | Aptcure Printravenousate Lintramuscularited |
| Atizor | Macter International (Pvt) Ltd. |
| Austa-Z | Bloom Pharmaceuticals (Pvt) Ltd. |
| Azelide | Hygeia Pharmaceuticals |
| Azi-Once Tablet | Crest Pharmaceuticals |
| Azia | Medera Pharmaceuticals (Pvt) Ltd. |
| Azic | Nabiqasintramuscular Industries (Pvt) Ltd. |
| Azintramuscularal | Shazals Pharmaceuticals |
| Azintramuscularycin | Mediceena Pharma (Pvt) Ltd. |
| Aziomak | Makson Pharmaceuticals |
| Aziotic | Everest Pharmaceuticals |
| Azir | Innvotek Pharmaceuticals |
| Azirol | Harmann Pharmaceutical Laboratories (Pvt) Ltd. |
| Azirom | Macquins International |
| Azisia | Ambrosia Pharmaceuticals |
| Azitab | Cherwel Pharmaceuticals (Pvt) Ltd |
| Azitab | Cherwel Pharmaceuticals (Pvt) Ltd |
| Azitek Tablet | Hygeia Pharmaceuticals |
| Azithro | Goodman Laboratories |
| Azithrosaf | Saaaf Pharmaceuticals |
| Azintravenouser | Florence Farmaceuticals (Pvt) Ltd |
| Aziwin | Jinnah Pharmaceuticals |
| Azizox | Alliance Pharmaceuticals (Pvt) Ltd. |
| Azobit | Wns Field Pharmaceuticals |
| Azogil | Glitz Pharma |
| Azoheintramuscular | Pakheintramuscular Internanational Pharma |
| Azolintravenouse | Olintravenouse Laboratories |
| Azopik | Wise Pharmaceuticals (Pvt) Ltd |
| Azotek | Saffron Pharmaceutical Company |
| Azure | Fynk Pharmaceuticals |
| Biozith | Bio Labs (Pvt) Ltd. |
| Blitz | Biogen Pharma |
| Caramycin | Caraway Pharmaceuticals |
| Conbac | Convell Laboratories |
| Delide | Dermagen Pharma Pakistan (Pvt) Lintramuscularited |
| Ery-Pack | Lowitt Pharmaceuticals (Pvt) Ltd |
| Exthro | Indus Pharma (Pvt) Ltd. |
| Ezmin | Honig Pharmaceuticals Laboratories |
| Fenzy | Noa Hemis Pharmaceuticals |
| Geozit | Geofman Pharmaceuticals |
| Grazeth | Gray`S Pharmaceuticals |
| Hyzitek | Hygeia Pharmaceuticals |
| Hyzitek | Hygeia Pharmaceuticals |
| Irzazitho | Irza Pharma (Pvt) Ltd. |
| Kinra | Tabros Pharma |
| Maczin | Mcolson Research Laboratories |
| Maksin | Trison Research Laboratories (Pvt) Ltd |
| Megatab | Robins Pharmaceutical Industries |
| Mezith | Qintar Pharmacuticals |
| Mynex | Nexus Pharma (Pvt) Ltd |
| Myzi | Pharmacare Laboratories (Pvt) Ltd. |
| Myzitro | Miracle Pharmaceuticals(Pvt) Ltd |
| Ottocin | Ottoman Pharma |
| Plazo | Platinum Pharmaceuticals (Pvt.) Ltd. |
| Rasmic | Rasco Pharma |
| Rasmic | Rasco Pharma |
| Rasmic | Rasco Pharma |
| Rasmic Forte | Rasco Pharma |
| Rasthro | Rasco Pharma |
| Reclocin | Zinta Pharmaceuticals Industries |
| Servaz | Kaizen Pharmaceuticals Pvt Ltd. |
| Silina | Fassgen Pharmaceuticals |
| Spell | Tagma Pharma (Pvt) Ltd. |
| Thron | Linear Pharma |
| Winzith | Pharmevo (Pvt) Ltd. |
| Zatrox | Usawa Pharmaceuticals |
| Zee | Danas Pharmaceuticals (Pvt) Ltd |
| Zeecin | Wilshire Laboratories (Pvt) Ltd. |
| Zeerox | Spl Pharmaceuticals (Pvt) Ltd |
| Zefed | Fedro Pharmaceutical |
| Zepack | Pearl Pharmaceuticals |
| Zesty | Innvotek Pharmaceuticals |
| Zetro | Getz Pharma Pakistan (Pvt) Ltd. |
| Zintramuscular | Genome Pharmaceuticals (Pvt) Ltd |
| Zintramuscular | Genome Pharmaceuticals (Pvt) Ltd |
| Zithin Tablet | Wisdom Therapeutics |
| Zithrosafe | Helicon Pharmaceutek Pakistan (Pvt) Ltd. |
| Zithrovel | Well & Well Pharma (Pvt) Ltd |
| Zithrowan | Swan Pharmaceuticals(Pvt) Ltd |
| Zitrex | Genome Pharmaceuticals (Pvt) Ltd |
| Zitrex | Genome Pharmaceuticals (Pvt) Ltd |
| Zitro | Glitz Pharma |
| Zomysin | Alkemy Pharmaceutical Laboratories (Printravenousate) Ltd. |
| Zycin | Everest Pharmaceuticals |
|
Azithromycin [Tabs 500 Mg] |
|
| Atizor | Macter International (Pvt) Ltd. |
| Azintramuscularic | Medera Pharmaceuticals (Pvt) Ltd. |
| Azithrosaf | Saaaf Pharmaceuticals |
| Azintravenouser | Florence Farmaceuticals (Pvt) Ltd |
| Azogil | Glitz Pharma |
| Azomax | Novartis Pharma (Pak) Ltd |
| Azomexin | Paramount Pharmaceuticals |
| Azopik | Wise Pharmaceuticals (Pvt) Ltd |
| Azotek | Saffron Pharmaceutical Company |
| Azure | Fynk Pharmaceuticals |
| Biozith | Bio Labs (Pvt) Ltd. |
| Ery-Pack | Lowitt Pharmaceuticals (Pvt) Ltd |
| Fenzy | Noa Hemis Pharmaceuticals |
| Grazeth | Gray`S Pharmaceuticals |
| Medi-Biotic | Medicon Pharmaceuticals Industries (Pvt) Ltd |
| Mynex | Nexus Pharma (Pvt) Ltd |
| Myzitro | Miracle Pharmaceuticals(Pvt) Ltd |
| Ottocin | Ottoman Pharma |
| Reclocin | Zinta Pharmaceuticals Industries |
| Servaz | Kaizen Pharmaceuticals Pvt Ltd. |
| Winzith | Pharmevo (Pvt) Ltd. |
| Zee | Danas Pharmaceuticals (Pvt) Ltd |
| Zeecin | Wilshire Laboratories (Pvt) Ltd. |
| Zefed | Fedro Pharmaceutical |
| Zetro | Getz Pharma Pakistan (Pvt) Ltd. |
| Zezot | Bosch Pharmaceuticals (Pvt) Ltd. |
| Zithrovel | Well & Well Pharma (Pvt) Ltd |
| Zithrowan | Swan Pharmaceuticals(Pvt) Ltd |
| Zitocin | Genera Pharmaceuticals |
| Zomax | Helix Pharma (Printravenousate) Lintramuscularited |
| Zycin | Everest Pharmaceuticals |
|
Azithromycin [Caps 250 Mg] |
|
| Acasia | Nexpharm |
| Acro | S.J. & G. Fazul Ellahie (Pvt) Ltd. |
| Akzith | Akson Pharmaceuticals (Pvt) Ltd. |
| Alide | Pharmix Laboratories (Printravenousate) Lintramuscularited. |
| Arcin | Linear Pharma |
| Athofix | The Schazoo Laboratories Ltd. |
| Azelide | Hygeia Pharmaceuticals |
| Azera | Medera Pharmaceuticals (Pvt) Ltd. |
| Azi-Once Capsule | Rotex Medica Pakistan (Pvt) Ltd |
| Azibect | Bryon Pharmaceuticals (Pvt) Ltd. |
| Azibect | Bryon Pharmaceuticals (Pvt) Ltd. |
| Azicin | Acme Laboratories Pakistan (Pvt) Ltd. |
| Azicure | Semos Pharmaceuticals (Pvt) Ltd. |
| Azidose | Shaheen Pharmaceuticals |
| Azigood | Goodman Laboratories |
| Azilite | Webros Pharmaceuticals |
| Azirolide | P.D.H. Pharmaceuticals (Pvt) Ltd. |
| Aziromycin | Nawan Laboratories (Pvt) Ltd. |
| Azit | Raazee Theraputics (Pvt) Ltd. |
| Azithadvan | Advanced Pharmaceuticals |
| Azithrocid | Unintravenousersal Enterprises |
| Azithrocin | Bex Pharma (Pvt) Ltd. |
| Azithromycin | Unipharma (Pvt) Ltd. |
| Azithrosaf | Saaaf Pharmaceuticals |
| Azithsun | Hisun Pharmaceuticals |
| Azitral | Nova Med Pharmaceuticals |
| Azix | Prays Pharmaceuticals |
| Azizen | Medizan Labs (Pvt) Ltd |
| Azo | Ethical Laboratories (Pvt) Ltd. |
| Azocure | Orta Labs. (Pvt) Ltd. |
| Azofas | Fassgen Pharmaceuticals |
| Azogen | Rogen Pharmaceuticals |
| Azolib | Stalwart Pharmaceuticals (Pvt) Ltd |
| Azom | Lotus Pharmaceuticals (Pvt) Ltd |
| Azomax | Novartis Pharma (Pak) Ltd |
| Azomed | Medera Pharmaceuticals (Pvt) Ltd. |
| Azomer | Miracle Pharmaceuticals(Pvt) Ltd |
| Azomin | Eg Pharmaceuticals |
| Azomite | Ambrosia Pharmaceuticals |
| Azomite | Ambrosia Pharmaceuticals |
| Azomycin | Pulse Pharmaceuticals |
| Azores | Saydon Pharmaceutical Industries (Pvt) Ltd. |
| Azorox | Caylex Pharmaceuticals (Pvt) Ltd. |
| Azotag | Biorex Pharmaceuticals |
| Azotine | Nintramuscularrall Laboratories |
| Azowin | Wise Pharmaceuticals (Pvt) Ltd |
| Azoxin | Flow Pharmaceuticals (Pvt) Ltd. |
| Azpar | Zesion Pharmaceutical (Pvt) Ltd |
| Azrocin | Obsons Pharmaceuticals |
| Azrowin | Wns Field Pharmaceuticals |
| Aztrix | Medisure Laboratories Pakistan (Pvt.) Ltd. |
| Azza | Genome Pharmaceuticals (Pvt) Ltd |
| Bactizith | W.Woodward Pakistan (Pvt) Ltd. |
| Carown | Crown Pharmaceuticals |
| Cinzit | Shrooq Pharmaceuticals |
| Clozip | Medisynth Pharmaceuticals |
| E-Thro | Olintravenouse Pharmaceuticals |
| Enzoxen | English Pharmaceuticals Industries |
| Ezill | Dr. Raza Pharma (Printravenousate) Lintramuscularited |
| Ezintramuscularax | Medipak Lintramuscularited |
| Ezonex | Mass Pharma (Printravenousate) Lintramuscularited |
| Ezonex | Mass Pharma (Printravenousate) Lintramuscularited |
| Fazi | Farm Aid Group Pak Ltd. |
| Geozit | Geofman Pharmaceuticals |
| Hazid | Gray`S Pharmaceuticals |
| Hith | Kanel Pharmaceuticals |
| Hyzith | Axis Pharmaceuticals |
| Irzazitho | Irza Pharma (Pvt) Ltd. |
| Kraze | Medicaids Pakistan (Pvt) Ltd. |
| Macro-Z | Z-Jans Pharmaceutical (Pvt) Ltd. |
| Macrobac | Continental Chemical Company (Pvt) Ltd. |
| Macrocap | Aries Pharmaceuticals (Pvt) Ltd |
| Macromax | Mega Pharmaceuticals (Pvt) Ltd |
| Macromyd | Global Pharmaceuticals |
| Macromyd | Global Pharmaceuticals |
| Macropore | Alson Pharmaceuticals |
| Macrozith | Rock Pharmaceuticals |
| Maxibest | Max Pharmaceuticals |
| Mylide | Envoy Pharma |
| Od-3 | Adamjee Pharmaceuticals (Pvt) Ltd. |
| Ram-Off | Valor Pharmaceuticals |
| Rayaz | Ray Pharma (Pvt) Ltd |
| Resque | Standpharm Pakistan (Pvt) Ltd. |
| Rezoxin | Reko Pharmacal (Pvt) Ltd. |
| Romy | Fozan Pharmaceuticals Industriers (Pvt) Ltd |
| Romycin | Surge Laboratories (Pvt) Ltd. |
| Rothin | Rakaposhi Pharmaceutical (Pvt) Ltd. |
| Sintramuscularzith | Sintramuscularz Pharmaceuticals |
| Syzcin | Sayyed Pharmaceuticals |
| Throb | Bio Labs (Pvt) Ltd. |
| Throb | Bio Labs (Pvt) Ltd. |
| Wazocin | Warafana Pharmaceuticals |
| Xabest | Everest Pharmaceuticals |
| Xiaxi | Evergreen Pharmaceuticals Pvt Lintramuscularited |
| Z-Mac | Opal Laboratories (Pvt) Ltd. |
| Zatrocin | Pearl Pharmaceuticals |
| Zemark | Unintramuscularark Pharmaceuticals |
| Zetro | Getz Pharma Pakistan (Pvt) Ltd. |
| Zewin | Orta Labs. (Pvt) Ltd. |
| Zezot | Bosch Pharmaceuticals (Pvt) Ltd. |
| Zicure | Medicaids Pakistan (Pvt) Ltd. |
| Ziromac | Zain Pharmaceutical |
| Ziromax | Polyfine Chempharma (Pvt) Ltd. |
| Zitamax (Zithromax) | Pfizer Laboratories Ltd. |
| Zith | Silver Oak Corporation. |
| Zithro | Unexo Labs (Pvt) Ltd. |
| Zithrofast | Medifine Laboratories |
| Zithromed | Medicraft Pharmaceuticals (Pvt) Ltd. |
| Zithrosan | Sante (Pvt) Lintramuscularited |
| Zithrovel | Well & Well Pharma (Pvt) Ltd |
| Ziton | Shawan Pharmaceuticals |
| Zomax | Helix Pharma (Printravenousate) Lintramuscularited |
| Zorix | Lahore Chemical & Pharmaceutical Works (Pvt) Ltd |
| Zotter | Highnoon Laboratories Ltd. |
| Zygrel | Searle Pakistan (Pvt.) Ltd. |
|
Azithromycin [Caps 500 Mg] |
|
| Acro | S.J. & G. Fazul Ellahie (Pvt) Ltd. |
| Azicure | Semos Pharmaceuticals (Pvt) Ltd. |
| Azilite | Webros Pharmaceuticals |
| Azithadvan | Advanced Pharmaceuticals |
| Azithromycin | Unipharma (Pvt) Ltd. |
| Azocam | Chas. A. Mendoza |
| Azogen | Rogen Pharmaceuticals |
| Azomed | Medera Pharmaceuticals (Pvt) Ltd. |
| Azomer | Miracle Pharmaceuticals(Pvt) Ltd |
| Azotine | Nintramuscularrall Laboratories |
| Azotine | Nintramuscularrall Laboratories |
| Azoxin | Flow Pharmaceuticals (Pvt) Ltd. |
| Azrowin | Wns Field Pharmaceuticals |
| Bactizith | W.Woodward Pakistan (Pvt) Ltd. |
| Cararox | Caraway Pharmaceuticals |
| D-Kortes | Zephyr Pharmatec (Pvt) Ltd. |
| E-Thro | Olintravenouse Pharmaceuticals |
| Hazid | Gray`S Pharmaceuticals |
| Macrozith | Rock Pharmaceuticals |
| Megazith | Crest Pharmaceuticals |
| Od-3 | Adamjee Pharmaceuticals (Pvt) Ltd. |
| Ram-Off | Valor Pharmaceuticals |
| Romy | Fozan Pharmaceuticals Industriers (Pvt) Ltd |
| Syzcin | Sayyed Pharmaceuticals |
| Zithromed | Medicraft Pharmaceuticals (Pvt) Ltd. |
| Zonacin | Akhai Pharmaceuticals. |
| Zygrel | Searle Pakistan (Pvt.) Ltd. |