Cefuroxime is a second-generation cephalosporin antibiotic available in the form of oral tablets, capsules, and suspension as well as in intravenous formulation for the treatment of the following infections:

• Treatment of bone and joint infections caused by:

  •  Penicillinase- and non-penicillinase-producing strains of Staphylococcus aureus.

    ---

• Treatment of mild to moderate acute bacterial exacerbations of chronic bronchitis in adults and adolescents older than 13 years of age caused by:

  • Streptococcus pneumoniae
  • Beta-lactamase negative strains of Haemophilus influenzae, or
  • Beta-lactamase negative strains of Haemophilus parainfluenzae.

    ---

• Treatment of lower respiratory tract infections including pneumonia caused by:

  • S. pneumoniae
  • H. influenzae including ampicillin resistant strains
  • Klebsiella spp.
  • Penicillinase- and non-penicillinase-producing strains of S. aureus
  • Streptococcus pyogenes
  • Escherichia coli.

    ---

• Treatment of adults and adolescents older than 13 years of age with early Lyme disease caused by:

  • Borrelia burgdorferi.

    ---

• Treatment of children older than 3 months of age with acute bacterial otitis media caused by:

  • S. pneumoniae
  • H. influenzae including beta-lactamase-producing strains
  • Moraxella catarrhalis including beta-lactamase-producing strains
  • S. pyogenes.

    ---

• Treatment of mild to moderate pharyngitis and tonsillitis caused by:

  • S. pyogenes

    ---

• Treatment of septicemia caused by:

  • Penicillinase- and nonpenicillinase- producing strains of S. aureus
  • S. pneumoniae
  • E. coli
  • H. influenzae including ampicillin resistant strains
  • Klebsiella spp.

    ---

• Treatment of mild to moderate acute bacterial maxillary sinusitis caused by:

  • S. pneumoniae
  • non-beta-lactamase producing strains of H. influenzae.

    ---

• Treatment of children older than 3 months of age with skin or soft tissue infections like impetigo caused by:

  • Staph. aureus including beta-lactamase-producing strains
  • S. pyogenes
  • E. coli
  • Klebsiella spp.
  • Enterobacter spp

• Prophylaxis of surgical infections

  ---

• Treatment of adults and children older than 3 months of age with urinary tract infections caused by:

  • E. coli
  • Klebsiella spp.

    ---

• Off-Label Use of Cefuroxime in Adults include:

  • Prophylaxis or treatment of animal or human bite Bite wound.
  • Mild to moderate Intra-abdominal community-acquired infection
  • In early disseminated or late Lyme disease.

Cefuroxime axetil dose in Adults:

• Off-label use as an alternative agent in the treatment of animal or human bite or prophylaxis of Bite wound:

  • 500 mg two times a day in combination with metronidazole or clindamycin for 3 - 5 days (for prophylaxis) or 5 - 14 days (for the treatment)

---

• Cefuroxime use in the treatment of acute exacerbation of Chronic obstructive pulmonary disease:

  • 250 to 500 mg two times a day for 5 - 7 days.

---

• Cefuroxime use as off-label use in mild to moderate community-acquired Intraabdominal infection:

  • Acute Cholecystitis:

    • 1.5 gms intravenous thrice daily for at least 24 hours (in combination with metronidazole ) after removal of the gallbladder or until clinical resolution.

• Other intraabdominal infections like a perforated appendix, diverticulitis, and intra-abdominal abscess:

  • 1.5 gms intravenous thrice daily in combination with metronidazole for 4 - 7 days following adequate source control.

---

• Cefuroxime use in the treatment of Lyme disease:

  • Early localized disease(erythema migrans):

    • 500 mg orally two times a day for 14 - 21 days.

  • Early disseminated disease as in carditis with 1st-degree atrioventricular block:

    • 500 mg orally two times a day for 21 - 28 days.

  • Early disseminated disease with mild neurologic involvement (isolated facial nerve palsy):

    • 500 mg orally two times a day for 14 - 21 days.

  • Late disease as in arthritis without neurologic involvement:

    • 500 mg orally two times a day for 28 days.

      ---

• Cefuroxime dose in Acute Otitis media:

  • 500 mg orally two times a day for 5 - 10 days.

---

• Cefuroxime axetil for outpatient empiric therapy or pathogen-directed therapy in community-acquired Pneumonia:

  • 500 mg orally two times a day for a minimum of 5 days in combination with other appropriate antibiotics such as macrolides.

    ---

• Cefuroxime as an alternative agent for Streptococcal pharyngitis:

  • 250 mg orally two times a day for 10 days.

---

• Cefuroxime for surgical prophylaxis in cardiac or head and neck surgery:

  • 1.5 gms intravenous within one hour prior to surgical incision.
  • The dose may be repeated within 4 hours in lengthy procedures and in patients with excessive blood loss.

---

• Cefuroxime axetil in Acute uncomplicated Urinary tract infections ( like Cystitis):

  • 250 mg orally two times a day for 5 - 7 days.

Cefuroxime dose in Childrens

General dosing of cefuroxime axetil in susceptible infections:

• Infants, Children, and Adolescents:

  • Mild to moderate infection:

    • 20 to 30 mg/kg/day orally in two divided doses to a maximum dose of 500 mg/dose.
    • 75 to 100 mg/kg/day intramuscular or intravenous in 3 divided doses to a maximum dose of 1.5 gms/dose

  • In Severe infections:

    • 100 - 200 mg/kg/day intramuscular or intravenous in 3 or 4 divided doses to a maximum dose of 1.5 gms/dose

---

Cefuroxime dose in Bone and joint infections:

• Infants older than 3 months, Children, and Adolescents:
  • 50 mg/kg/dose intramuscular or intravenous thrice daily to a maximum dose of 1.5 gms/dose.

---

Cefuroxime dose in acute exacerbations of Chronic Bronchitis:

• Adolescents:
  • 250 - 500 mg orally twice daily for 10 days

---

Zinacef (Cefuroxime) dose in Impetigo:

• Infants older than 3 months and Children:
  • 15 mg/kg/dose orally (suspension) two times a day for 10 days to a maximum dose of 500 mg/dose.

---

Cefuroxime dose in complicated community-acquired Intra-abdominal infections:

• Infants, Children, and Adolescents:
  • 150 mg/kg/day intravenous in three or four divided doses to a maximum dose of 1.5 gms/dose.

---

Cefuroxime dose in Lyme disease:

• Infants, Children, and Adolescents:

  • Acrodermatitis Chronica atrophicans:

    • 15 mg/kg/dose orally twice daily for 21 days to a maximum dose of 500 mg/dose.

  • Early localized disease:

    • 15 mg/kg/dose orally twice daily for 14 days to a maximum dose of 500 mg/dose.

  • Late disease as in arthritis:

    • 15 mg/kg/dose orally twice daily for 28 days to a maximum dose of 500 mg/dose.

---

Cefuroxime dose in Acute Otitis media:

• Infants older than 3 months and Children:
  • 15 mg/kg/dose orally (suspension) two times a day for 10 days to a maximum dose of 500 mg/dose or
  • 250 mg of oral tablets two times a day for 10 days (in patients who can swallow the tablets.

---

Cefuroxime dose in Pharyngitis & tonsillitis:

• Infants older than 3 months and Children:

  • 10 mg/kg/dose orally (suspension) two times a day for 10 days to a maximum dose of 250 mg/dose.

• Adolescents:

  • 250 mg of oral tablets two times a day for 10 days.

---

Cefuroxime dose in Bacterial Pneumonia in HIV-exposed or HIV-positive patients:

• Infants and Children:
  • 35 - 50 mg/kg/dose intravenous thrice daily to a maximum dose of 2 gms/dose.

---

Cefuroxime dose in Sinusitis:

• Infants older than 3 months and Children:

  • 15 mg/kg/dose orally (suspension) two times a day for 10 days to a maximum dose of 500 mg/dose or
  • 250 mg oral tablets two times a day for 10 days

• Adolescents:

  • 250 mg oral tablets two times a day for 10 days

---

Cefuroxime dose in Uncomplicated Skin and soft-tissue infections:

• Adolescents:
  • 250 - 500 mg oral tablets two times a day for 10 days

---

Cefuroxime dose in Surgical prophylaxis:

• Children and Adolescents:
  • 50 mg/kg intravenous within one hour before the procedure.
  • The dose may be repeated in four hours in lengthy procedures or in patients with excessive blood loss (more than 1.5 liters) to a maximum dose of 1.5 gms/dose.

---

Cefuroxime dose in Uncomplicated Urinary tract infection:

• Infants and Children 2 - 24 months:

  • 10 to 15 mg/kg/dose orally (suspension) two times a day.

• Children older than 2 years:

  • Moderate to severe disease including the possibility of pyelonephritis:
    • 20 to 30 mg/kg/day orally (suspension) in two divided doses to a maximum dose of 500 mg/dose.

• Adolescents:

  • 250 mg oral tablets two times a day for 7 - 10 days

Cefuroxime Pregnancy Risk Factor B

• Cefuroxime crosses over the placenta but has not been linked to any adverse effects in fetal health.
• It is recommended for prophylactic use prior to cesarean delivery.

Cefuroxime axetil use during breastfeeding:

• Breast milk contains cefuroxime, which is excreted in it.
• While it is generally compatible with breastfeeding, infants should be monitored for any gastrointestinal disturbances, including vomiting and diarrhea.

Cefuroxime dose in Renal disease:

• Dose adjustment for oral tablets as per Manufacturer’s labeling:

  • CrCl of 30 mL/minute or more:

    • Dose adjustment is not required

  • CrCl 10 - 30 mL/minute:

    • Administer the recommended dose once a day.

  • CrCl of less than 10 mL/minute:

    • Administer the recommended dose every 2nd day.

  • ESRD requiring intermittent hemodialysis (IHD):

    • Give an additional recommended dose after each dialysis.

• Dose adjustment for Intravenous Cefuroxime as per Manufacturer’s labeling:

  • CrCl of 20 mL/minute or more:

    • Dose adjustment is not required

  • CrCl 10 - 20 mL/minute:

    • Administer the recommended dose twice daily

  • CrCl of less than 10 mL/minute:

    • Administer the recommended dose once a day.

  • Patient with Hemodialysis:

    • Administer an additional recommended dose after dialysis.

      ---

• Alternative dosing of Cefuroxime axetil:

  • Peritoneal dialysis:

    • Administer the recommended dose once a day.

  • Continuous renal replacement therapy (CRRT):

    • 1 gm twice daily

Cefuroxime axetil (ZInacef) dose in liver disease:

Dose adjustment in patients with liver disease is not recommended.

Cefuroxime axetil Side effects (Common):

• Gastrointestinal:

  • Diarrhea

Less Common Side Effects Of Cefuroxime (Zinacef) include:

• Cardiovascular:

  • Local thrombophlebitis

• Dermatologic:

  • Diaper rash

• Endocrine & metabolic:

  • Increased lactate dehydrogenase

• Gastrointestinal:

  • Nausea and vomiting
  • Unpleasant taste

• Genitourinary:

  • Vaginitis

• Hematologic & oncologic:

  • Decreased hematocrit
  • Decreased hemoglobin
  • Eosinophilia

• Hepatic:

  • Increased serum transaminases
  • Increased serum alkaline phosphatase

• Immunologic:

  • Jarisch-Herxheimer reaction

Contraindication to Cefuroxime include:

• Allergy reactions to cefuroxime or other beta-lactam antibiotic drugs, penicillins or cephalosporins and any component of this formulation

Zinacef Warnings and Precautions

• Elevated INR

  • A rise in INR can lead to coagulopathy, which may be a sign of Cefuroxime therapy for patients with nutritional deficiencies or hepatic impairment.

• Hypersensitivity reactions

  • Anaphylactic reactions can occur.
  • It is important to stop using the drug and immediately start treatment with antihistamines, epinephrine and steroids.

• Superinfection

  • Cefuroxime therapy for longer periods (more than two months) can lead to superinfections, including fungal or bacterial superinfections. C. difficile-associated diarrhea, (CDAD), and pseudomembranous collitis can occur.

• Gastrointestinal Disease:

  • Patients who have had colitis in the past should not take this drug.

• Renal impairment

  • Patients with impaired renal function should be cautious when taking the drug. Adjusting the dose may be necessary.

• Seizure disorders:

  • Seizures can occur in patients who are taking high doses or those with impaired renal function. 
  • Patients with seizure disorders or a history of seizures should not take this medication.

Cefuroxime: Drug Interaction

Note: Drug Interaction Categories:

• Risk Factor C: Monitor When Using Combination
• Risk Factor D: Consider Treatment Modification
• Risk Factor X: Avoid Concomitant Use

Risk Factor C (Monitor therapy).
Aminoglycosides	Cephalosporins (2nd generation) can increase the nephrotoxic effects of Aminoglycosides.
BCG Vaccine (Immunization)	Antibiotics can decrease the therapeutic effects of BCG Vaccine (Immunization).
Lactobacillus & Estriol	Antibiotics can reduce the therapeutic effects of Lactobacillus or Estriol.
Probenecid	May increase serum Cephalosporins.
Vitamin K antagonists (e.g. warfarin).	Cephalosporins can increase the anticoagulant effects of Vitamin K Antagonists.
Risk Factor D (Take into account therapy modification)
Antacids	The serum concentration of Cefuroxime may be decreased. Management: Cefuroxime Axetil should be administered at least one hour before or two hours after administration of short-acting antibiotics.
Sodium Picosulfate	Antibiotics can reduce the therapeutic effects of Sodium Picosulfate. Patients who are currently using or have just finished using antibiotics should consider using an alternative product to cleanse the bowels before undergoing a colonoscopy.
Typhoid Vaccine	The therapeutic effects of Typhoid vaccine may be diminished by antibiotics. The only affected strain is the live attenuated Ty21a. Patients being treated with systemic antibiotics should avoid vaccination with live attenuated Typhoid vaccine (Ty21a). This vaccine should not be used until at least three days after the cessation or discontinuance of antibacterial agents.
Risk Factor X (Avoid Combination)
BCG (Intravesical).	The therapeutic effects of BCG (Intravesical) may be diminished by antibiotics
Cholera Vaccine	Cholera Vaccine may be less effective if taken with antibiotics. Treatment: Cholera vaccine should be avoided in patients who have received systemic antibiotics.
Histamine H2 Receptor Antagonists	This may decrease Cefuroxime absorption. Separate oral doses for at least 2 hours
Inhibitors of the proton pump	This may decrease Cefuroxime absorption.

Monitor (periodically with prolonged therapy):​​​​​​​

• Renal functions
• Liver functions
• CBC & other hematologic parameters
• Prothrombin time and INR especially in malnourished individuals
• Observe for clinical features of anaphylaxis during the first dose.

How to take Cefuroxime axetil?

• Oral suspension:

  • Shake the suspension well before use and administer with meals.

• Oral tablet:

  • Oral tablets have a very bitter taste and should be swallowed whole with or without food.

• Intramuscular injection:

  • Inject deep IM into large muscle mass.

• Intravenous:

  • Inject intravenously directly direct over 3 - 5 minutes. IV Infusion may be given over 15 - 30 minutes.

Mechanism of action of Cefuroxime axetil:

CefuroximeBy binding to penicillin-binding proteins, it inhibits the formation proteins and peptidoglycans. This eventually leads to cell lysis through the autolytic enzymes.

The absorbtion ofOral tablets increase with food It is widely availableTo body tissues and fluids such as bronchial secretions and synovial and pericardial fluids, kidneys, liver and heart, bone and bile.

 It crosses the blood-brain border. 33 to 50% of the drug areprotein-bound.Oral Cefuroxime Axetil is metabolized by the intestinal mucosa.

BioavailabilityThe oral tablet's efficiency is 37% when consumed in fasting. When taken with food, the bioavailability of the oral tablet is up to 50%. The oral suspension is less bioavailable.

Half-life eliminationAdults can take the drug for 1 to 2 hours while children need it for 1.4 to 1.9 hours. It increases in patients with kidney failure, neonatal and premature babies.

Time to get therepeak serum concentrationAfter intramuscular injection, it takes 15 to 60 minutes. After intravenous injection, it takes 2 – 3 minutes. Oral administration takes 3 – 4 hours.

It is primarilyexcretedVia urine (66 - 100%) .

Cefuroxime axetil Brand Names (International):

• APO-Cefuroxime
• Auro-Cefuroxime
• Ceftin
• PRO-Cefuroxime-500
• RATIO-Cefuroxime
• Actixim
• Adrox
• Aksef
• Alporin
• Altacef
• Altamax
• Anbacim
• Aprok
• Aprokam
• Axet
• Axetine
• Axim
• Axurocef
• C-Tri T
• Carvixime
• Cef2
• Cefabiot
• Cefasun
• Cefero
• Ceflour
• Cefmono
• Cefora
• Cefosan
• Ceftil
• Cefudura
• Cefuhexal
• Cefumax
• Cefuracet
• Cefurax
• Cefuro-Puren
• Cefurocos
• Cefurox
• Cefuroxwolff
• Cefutil
• Cefutin
• Cefuxime
• Cefxin
• Cefzime
• Celocid
• Ceprosim
• Cerox A
• Ceroxim
• Cethixim
• Cetil
• Cetoxil
• Cexil
• Cexim
• CMaxid
• Cortum
• Curoxime
• Daliroxim
• Daroxime
• Daroxine
• Deltrox
• Efox
• Efurox
• Elobact
• Eroxmit
• Famicef
• Farmacef
• Fornax
• Froxime
• Furacam
• Furobioxin
• Furoxim
• Furoxime
• Gomcef
• Jectocef
• Keef-250
• Kefezy
• Kefloxa
• Kefrox
• Kefurox
• Ketocef
• Kimatcef
• Magnaspor
• Maxil
• Medxime
• Milcef
• Neurox-250
• Novador
• Novocef
• Olcef
• Oratil
• Oraxim
• Oxtercid
• Profurex
• Rucef
• Sefuxim
• Sharox-500
• Shincef
• Situroxime
• Teikeden
• U-Cef
• Vekfazolin
• Vexuro
• Xorim
• Xorimax
• Xorufec
• Zamur
• Zegen
• Zenon
• Zetnil
• Zilisten
• Zinacef
• Zinat
• Zincef
• Zinnat
• Zinoximor
• Zocef
• Zoref

Cefuroxime axetil Brand Names in Pakistan:

Cefuroxime injection 1 gm
Ezoxo	English Pharmaceuticals Industries
Optik	Wilshire Laboratories (Pvt) Ltd.
Trucef	Synchro Pharmaceuticals

 

Cefuroxime injection 1.5 gm
Aloxime	Macquins International
Cefozine	Trigon Pharmaceuticals Pakistan (Pvt) Ltd.
Cefro-Z	Z-Jans Pharmaceutical (Pvt) Ltd.
Cefurox	Medicaids Pakistan (Pvt) Ltd.
Cefusave	Medisave Pharmaceuticals
Cefuzin	P.D.H. Pharmaceuticals (Pvt) Ltd.
Dowcef	Martin Dow Pharmaceuticals (Pak) Ltd.
Dowcef	Martin Dow Pharmaceuticals (Pak) Ltd.
Fortaran	Zinta Pharmaceuticals Industries
Heli-Rox	Ipram International
Imroxime	Imco Pharmaceuticals Laboratories
Keekol	Karachi Pharmaceutical Laboratory
Kefrox	Consolidated Chemical Laboratories (Pvt) Ltd.
Libroxin	Libra Pharmaceuticals (Pvt) Ltd
Marcef	Lowitt Pharmaceuticals (Pvt) Ltd
Mediroxine	Mediate Pharmaceuticals (Pvt) Ltd
Nipogalin	A.J. & Company.
Optik	Wilshire Laboratories (Pvt) Ltd.
Otim	Neutro Pharma (Pvt) Ltd.
Rubact	Silver Oak Corporation.
Safme	Saydon Pharmaceutical Industries (Pvt) Ltd.
Uswaxime	Usawa Pharmaceuticals
Zecef	Bosch Pharmaceuticals (Pvt) Ltd.
Zinacef	Glaxosmithkline

 

Cefuroxime injection 125 mg
Cefusave	Medisave Pharmaceuticals

 

Cefuroxime injection 250 mg
Alfur	Albro Pharma
Aloxime	Macquins International
Biroxime	Wise Pharmaceuticals (Pvt) Ltd
Cefozine	Trigon Pharmaceuticals Pakistan (Pvt) Ltd.
Cefro-Z	Z-Jans Pharmaceutical (Pvt) Ltd.
Cefurox	Medicaids Pakistan (Pvt) Ltd.
Cefusave	Medisave Pharmaceuticals
Cefuzin	P.D.H. Pharmaceuticals (Pvt) Ltd.
Dowcef	Martin Dow Pharmaceuticals (Pak) Ltd.
Dowcef	Martin Dow Pharmaceuticals (Pak) Ltd.
Elfurox	Elko Organization (Pvt) Ltd.
Evorox	Pharmevo (Pvt) Ltd.
Ezoxo	English Pharmaceuticals Industries
Fortaran	Zinta Pharmaceuticals Industries
Grefidim	Akson Pharmaceuticals (Pvt) Ltd.
Heli-Rox	Ipram International
Keekol	Karachi Pharmaceutical Laboratory
Kefrox	Consolidated Chemical Laboratories (Pvt) Ltd.
Libroxin	Libra Pharmaceuticals (Pvt) Ltd
Lictyn	Caraway Pharmaceuticals
Marcef	Lowitt Pharmaceuticals (Pvt) Ltd
Mediroxine	Mediate Pharmaceuticals (Pvt) Ltd
Miroxim	Linz Pharmaceuticals (Pvt) Ltd.
Moxime	Standpharm Pakistan (Pvt) Ltd.
Optik	Wilshire Laboratories (Pvt) Ltd.
Otim	Neutro Pharma (Pvt) Ltd.
Rubact	Silver Oak Corporation.
Safme	Saydon Pharmaceutical Industries (Pvt) Ltd.
Supero	Scharper Pharmaceuticals (Pvt) Ltd.
Tiracef	Mass Pharma (Private) Limited
Trucef	Synchro Pharmaceuticals
Zafurox	Zafa Pharmaceutical Laboratories (Pvt) Ltd.
Zecef	Bosch Pharmaceuticals (Pvt) Ltd.
Zinacef	Glaxosmithkline
Zinorox	Goodman International,

 

Cefuroxime injection 500 mg
Ezoxo	English Pharmaceuticals Industries
Optik	Wilshire Laboratories (Pvt) Ltd.
Trucef	Synchro Pharmaceuticals

 

Cefuroxime injection 750 mg
Alfur	Albro Pharma
Aloxime	Macquins International
Biroxime	Wise Pharmaceuticals (Pvt) Ltd
Cefozine	Trigon Pharmaceuticals Pakistan (Pvt) Ltd.
Cefucef	Pharmedic (Pvt) Ltd.
Cefurox	Medicaids Pakistan (Pvt) Ltd.
Cefusave	Medisave Pharmaceuticals
Cefuzin	P.D.H. Pharmaceuticals (Pvt) Ltd.
Dowcef	Martin Dow Pharmaceuticals (Pak) Ltd.
Dowcef	Martin Dow Pharmaceuticals (Pak) Ltd.
E-Xim	Linear Pharma
Elfurox	Elko Organization (Pvt) Ltd.
Evorox	Pharmevo (Pvt) Ltd.
Fortaran	Zinta Pharmaceuticals Industries
Heli-Rox	Ipram International
Imroxime	Imco Pharmaceuticals Laboratories
Keekol	Karachi Pharmaceutical Laboratory
Kefrox	Consolidated Chemical Laboratories (Pvt) Ltd.
Libroxin	Libra Pharmaceuticals (Pvt) Ltd
Lictyn	Caraway Pharmaceuticals
Marcef	Lowitt Pharmaceuticals (Pvt) Ltd
Mediroxine	Mediate Pharmaceuticals (Pvt) Ltd
Miroxim	Linz Pharmaceuticals (Pvt) Ltd.
Moxim	Shafaz Pharma International (Pvt) Ltd.
Moxime	Standpharm Pakistan (Pvt) Ltd.
Neveroz	Spadix Pharmaceuticals
Nipogalin	A.J. & Company.
Optik	Wilshire Laboratories (Pvt) Ltd.
Otim	Neutro Pharma (Pvt) Ltd.
Phaxef	Pharmacare Laboratories (Pvt) Ltd.
Rox-Z	Z-Jans Pharmaceutical (Pvt) Ltd.
Roxime	Rehman Medicine Co.
Rubact	Silver Oak Corporation.
Safme	Saydon Pharmaceutical Industries (Pvt) Ltd.
Seroxin	Qureshi Pharma (Pvt) Ltd.
Shincef	Medisure Laboratories Pakistan (Pvt.) Ltd.
Tiracef	Mass Pharma (Private) Limited
Warox	Usawa Pharmaceuticals
Zafurox	Zafa Pharmaceutical Laboratories (Pvt) Ltd.
Zecef	Bosch Pharmaceuticals (Pvt) Ltd.
Zinacef	Glaxosmithkline
Zinorox	Goodman International,

 

Cefuroxime injection 250 mg (IM and IV)
Bloxime	Bloom Pharmaceuticals (Pvt) Ltd.

 

Cefuroxime injection 750 mg (IM and IV)
Bloxime	Bloom Pharmaceuticals (Pvt) Ltd.

 

Cefuroxime Suspension 125 mg/5ml
Alfur	Albro Pharma
Apotex	Nova Med Pharmaceuticals
Astalexim	Astellas Pharmaceuticals
Benroxim	Benson Pharamceuticals.
Ceforal	Gray`S Pharmaceuticals
Cefrox	Agror Pharma
Cefroxil	Friends Pharma (Pvt) Ltd
Cefurox	Medicaids Pakistan (Pvt) Ltd.
Celoxime	Mega Pharmaceuticals (Pvt) Ltd
Daycef	Shrooq Pharmaceuticals
Dowcef	Martin Dow Pharmaceuticals (Pak) Ltd.
Elfurox	Elko Organization (Pvt) Ltd.
Evorox	Pharmevo (Pvt) Ltd.
Heli-Rox	Ipram International
Imroxime	Imco Pharmaceuticals Laboratories
Intracef	Fassgen Pharmaceuticals
Itlon	Lexicon Pharmaceuticals (Pvt) Ltd.
Kefrox	Consolidated Chemical Laboratories (Pvt) Ltd.
Mediroxine	Mediate Pharmaceuticals (Pvt) Ltd
Optik	Wilshire Laboratories (Pvt) Ltd.
Protex	Wns Field Pharmaceuticals
Warox	Usawa Pharmaceuticals
Zecef	Bosch Pharmaceuticals (Pvt) Ltd.
Zeolot	Fynk Pharmaceuticals
Zerox	Goodman Laboratories
Zinacef	Glaxosmithkline
Zinnat	Glaxosmithkline

 

Cefuroxime Suspension 250 mg/5ml
Astalexim	Astellas Pharmaceuticals
Optik	Wilshire Laboratories (Pvt) Ltd.
Saferoxime	Safe Pharmaceutical (Pvt) Ltd.

 

Cefuroxime Tablets 125 mg
Benroxim	Benson Pharamceuticals.
Cefurox	Medicaids Pakistan (Pvt) Ltd.
Cefuzin	P.D.H. Pharmaceuticals (Pvt) Ltd.
Dowcef	Martin Dow Pharmaceuticals (Pak) Ltd.
Evorox	Pharmevo (Pvt) Ltd.
Marcef	Lowitt Pharmaceuticals (Pvt) Ltd
Mediroxine	Mediate Pharmaceuticals (Pvt) Ltd
Roxat	Helicon Pharmaceutek Pakistan (Pvt) Ltd.
Zecef	Bosch Pharmaceuticals (Pvt) Ltd.
Zinacef	Glaxosmithkline
Zinnat	Glaxosmithkline

 

Cefuroxime Tablets 250 mg
Benroxim	Benson Pharamceuticals.
Cefroxil	Friends Pharma (Pvt) Ltd
Cefurox	Medicaids Pakistan (Pvt) Ltd.
Cefuzin	P.D.H. Pharmaceuticals (Pvt) Ltd.
Dowcef	Martin Dow Pharmaceuticals (Pak) Ltd.
Evorox	Pharmevo (Pvt) Ltd.
Kefrox	Consolidated Chemical Laboratories (Pvt) Ltd.
Marcef	Lowitt Pharmaceuticals (Pvt) Ltd
Mediroxine	Mediate Pharmaceuticals (Pvt) Ltd
Roxat	Helicon Pharmaceutek Pakistan (Pvt) Ltd.
Xurox	Siza International (Pvt) Ltd.
Zecef	Bosch Pharmaceuticals (Pvt) Ltd.
Zinacef	Glaxosmithkline
Zinnat	Glaxosmithkline

 

Cefuroxime Capsules 125 mg
Ceforal	Gray`S Pharmaceuticals
Trucef	Synchro Pharmaceuticals

 

Cefuroxime Capsules 250 mg
Alfur	Albro Pharma
Cef-Euro	Rasco Pharma
Ceforal	Gray`S Pharmaceuticals
Cefrox	Agror Pharma
Cefusave	Medisave Pharmaceuticals
Daycef	Shrooq Pharmaceuticals
Imroxime	Imco Pharmaceuticals Laboratories
Lictyn	Caraway Pharmaceuticals
Setrozim	Spl Pharmaceuticals (Pvt) Ltd
Warox	Usawa Pharmaceuticals

 

Cefuroxime Capsules 500 mg
Trucef	Synchro Pharmaceuticals