Homatropine Eye Drops are used to produce mydriasis as in patients undergoing refractory surgery. It is also used in patients with uveitis.

Homatropine Eye Drops Uses:

• Mydriasis and cycloplegia for refraction:

  • It is used to produce mydriasis before and after surgery (producing cycloplegia and mydriasis for refraction).

• Optical aid:

  • It may be used as an optical aid in cases of axial lens opacities.

• Uveitis:

  • It is used to treat the inflammatory conditions of the uveal tract.

Homatropine Dose in Adults

Note: Patients with heavily pigmented irides may require higher doses.

Homatropine Dose in the treatment of Refraction:

• Ophthalmic: 2% or 5% solution:
  • Instill 1 to 2 drops into the affected eye.
  • The dose may be repeated in 5 to 10 minutes if necessary

Homatropine eye drops Dose in the treatment of Uveitis:

• Ophthalmic: 2% or 5% solution:
  • Instill 1 to 2 drops into the affected eye every 3 to 4 hours or as advised by the physician.

Homatropine Dose in Cildrens

Note: Patients with heavily pigmented irides may require higher doses.

Homatropine dose in the treatment of Mydriasis and cycloplegia for refraction:

• Infants ≥3 months, Children, and Adolescents:

  • Ophthalmic: 5% solution:
    • Instill 1 to 2 drops into the affected eye immediately before the procedure.
    • The dose may be repeated once in 5 to 10 minutes if required.

Homatropine eye drops dose in the treatment of Uveitis:

• Infants ≥3 months, Children, and Adolescents:

  • Ophthalmic: 5% solution:
    • Instill 1 to 2 drops into the affected eye every 3 to 4 hours or as advised by the healthcare expert.

Pregnancy Risk Factor C

• It has not yet been tested in human or animal pregnancies.

Use during breastfeeding:

• It is unknown if the drug is excreted into breastmilk. It is recommended that breastfeeding mothers avoid using the drug.

Dose in Kidney Disease:

There are no dosage adjustments provided in the manufacturer’s labeling.

Dose in Liver disease:

There are no dosage adjustments provided in the manufacturer’s labeling.

Side effects of Homatropine eye drops:

• Cardiovascular:

  • Edema

• Central Nervous System:

  • Burning Sensation
  • Stinging Sensation

• Dermatologic:

  • Eczema

• Endocrine & Metabolic:

  • Increased Thirst

• Gastrointestinal:

  • Xerostomia

• Local:

  • Local Irritation

• Ophthalmic:

  • Blurred Vision
  • Follicular Conjunctivitis
  • Increased Intraocular Pressure
  • Ocular Exudate
  • Photophobia
  • Vascular Congestion Of The Eye

Contraindications to Homatropine eye drops:

• Patients who have had glaucoma in the past or are at high risk for developing it (such as those with narrow anterior rooms).
• Allergy reactions to any component of the drug or the drug itself
• Cross-reactivity to belladonna alkaloids may occur because of the similarities in structure, however, data is limited.

Warnings and precautions

• CNS effects

  • Neurological symptoms may include confusion, delirium and agitation. Excessive use of medicine can cause neurologic symptoms.
  • Although neurological symptoms can occur in any age group, they are more common in children and the elderly.
  • Patients who are required to be alert for tasks such as driving heavy machinery or operating heavy machinery should not take this drug.

• Ocular light sensitivity:

  • To avoid ocular hypersensitivity, patients should be taught to use sunglasses and appropriate eye protection after applying the eye drops.

• Down syndrome

  • Angle-closure Glaucoma should be checked in patients with Down syndrome before they use the eye drops. These patients are more likely to develop angle-closure.

• Keratoconus

  • Patients with Keratoconus should use it with caution as fixed pupillary dilation could occur.

Homatropine: Drug Interaction

Monitoring Parameters:

None mentioned. Monitor the response to treatment.

How to administer Homatropine eye drops?

Ophthalmic instillation:

• Wash hands when instilling the eye drops and remove contact lenses. Avoid touching the tip of the applicator to the surrounding skin, eyelashes, or other ocular structures.
• To reduce the chances of systemic absorption, press the lacrimal sac for 1 - 3 minutes after instilling the eye drops.
• Contact lenses can be worn after 10 to 15 minutes. If the eyes are red or inflamed, avoid wearing contact lenses.

Mechanism of action of Homatropine:

• It dilates pupils (mydriasis), and causes cycloplegic (loss of or paralysis) of accommodation. 
• It inhibits the response of the ocular muscles to cholinergic stimulation (iris sphincter muscle and muscles of the ciliary organ).

International Brand Names of Homatropine eye drops:

• Homatropaire
• Isopto Homatropine
• Bernardtropina
• Bromhydrate d'homatropine-Chauvin
• Hemasol
• Hemomin
• Homapin
• Homarin Forte
• Homatogen
• Homatropin
• HomatropinPOS
• Homatropina
• Homatropine
• Homatropine Faure
• Homo Grin
• Isopto Homatropine
• Isopto-Homatropine
• Matropin
• Minims Homatropine
• Minims Homatropine Hydrobromide
• Minims-Homatropinhydrobromid
• Ocuhomapine
• Omatropina
• Paratropina

Homatropine Brand Names in Pakistan: