Nonoxynol 9 Spermicide Contraceptive - Use, Side effects, Brands

Nonoxynol 9 is a surfactant and is present in most cosmetic formulations. It is commonly used as a spermicidal agent when used intravaginally. Thus, it is used as a locally acting non-hormonal contraceptive agent.

Nonoxynol 9 Uses:

Contraception:
- Prevention of pregnancy

Nonoxynol 9 Dose in Adults

Nonoxynol 9 use for Contraception in Females:

Intravaginal:

Note:

Additional application may be necessary, if repeated intercourse takes place.
Refer to the specific product labeling for complete instructions, Prior to use.
Encare 100 mg:
- At least 10 mins prior to intercourse, unwrap and insert 1 suppository vaginally.
- 1-hour effectivity.
Options Conceptrol Gel 4 percent:
- Insert 1 applicatorful (100 mg) vaginally immediately prior to intercourse
- 1-hour effectivity.
Options Gynol II gel 3 percent:
- Insert 1 applicatorful (150 mg) vaginally immediately prior to intercourse.
- 1-hour effectivity.
- Apply 1 applicatorful (approximately 1 teaspoonful) of gel onto the dome of the diaphragm and spread around the edge using fingertip prior to inserting, if used with a diaphragm.
- Additional application of gel is needed, if intercourse occurs >6 hours after insertion, or if repeated intercourse occurs.
- To reapply, Do not remove the diaphragm.
- Use the applicator to apply the gel, taking care not to dislodge the diaphragm.
Today:
- Insert 1 sponge (1,000 mg) vaginally prior to intercourse.
- Before removing, allow remaining in place for 6 hours after intercourse.
- Effective for use up to 24 continuous hours.
- Do not leave in place for >30 hours.
VCF:
- Film 28 percent:
  - Prior to intercourse, Insert 1 film vaginally at least 15 mins, but no more than 3 hours.
  - Insert new film for each act of intercourse or if more than 3 hours have elapsed.
- Foam 12.5 percent:
  - Insert 1 applicatorful no more than 1 hour prior to intercourse.
  - Effective for up to 1 hour.

Nonoxynol 9 Dose in Childrens

Nonoxynol 9 Dose use for Contraception:

Adolescents:
- Females:
  - Intravaginal:
    - Refer to adult dosing.
    - Not for use prior to menarche.

Pregnancy Implications:

The use of spermicides has not been associated with birth defects.
In the prevention of pregnancy, the effectiveness of available nonoxynol 9-containing products is similar.
However, the percentage of unintended pregnancies following the use of these products is generally greater than with other methods of contraception.
Many can be used with a diaphragm & male condom.
To reduce the risk for sexually transmitted disease and HIV transmission, consistent and correct use of the male latex condom is recommended and provides an additional method of contraception.
For use in women, barrier contraceptives may not be appropriate in which the risk of pregnancy is unacceptable due to other health conditions, because of their relatively higher failure rate if not used correctly.

Dose in Kidney Disease:

In the manufacturer's labeling, there are no dosage adjustments provided .
For use in women, barrier contraceptives may not be appropriate in which the risk of pregnancy is unacceptable due to other health conditions, because of their relatively higher failure rate if not used correctly.

Dose in Liver Disease:

In the manufacturer's labeling, there are no dosage adjustments provided.
For use in women, barrier contraceptives may not be appropriate in which the risk of pregnancy is unacceptable due to other health conditions, because of their relatively higher failure rate if not used correctly.

Side effects of Nonoxynol 9:

Genitourinary:
- Mucous membrane disease (burning, irritation, pruritus; including vaginal/urethral)

Contraindications to Nonoxynol 9:

OTC labeling:

Do not use if you or your sex partner has HIV/AIDS, when used for self-medication.

Today only: Do not use:

If allergic to nonoxynol 9 or any component of the formulation.
If allergic to sulfites.
Within 6 weeks after giving birth.
History of toxic shock syndrome.
During the menstrual period.

Warnings and Precautions

Toxic shock syndrome:
- Has been reported with barrier contraceptive use.
Vaginal irritation:
- May cause vaginal irritation (eg, burning, itching, or rash).
- Irritation may be associated with an increased risk of getting HIV from an infected partner.

Monitoring parameters:

None mentioned.

How to administer Nonoxynol 9?

Intravaginal:

For vaginal use only.
Not for rectal use.

Today:

Prior to use, wet the sponge with clean water and squeeze gently until sudsy in order to activate spermicide.
Fold sponge in half with dimple side inside and string loop on the bottom end, then insert into the vagina.
Prior to intercourse, it may be inserted up to 24 hours.
If it accidentally falls out, Sponge should not be reinserted (insert new sponge).
Do not reuse sponge.

VCF:

Film:
- Before touching film, fingers should be dry.
- Remove film from pouch & fold in half.
- Using a finger, insert vaginally.
Foam:
- Prior to use, shake well.

Mechanism of action of Nonoxynol 9:

Nonoxynol 9 is a nonionic surfactant which prevents pregnancy by damaging the cell membrane of sperm.
A physical barrier may also be provided by some product formulations.