Tyzine (Tetrahydrozoline Nasal Spray) is a sympathomimetic drug that causes vasoconstriction of the blood vessels. It is used as a nasal spray for the relief of nasal congestion associated with allergies.

Tyzine (Tetrahydrozoline Nasal Spray) Uses:

• It is used for the symptomatic treatment of nasal congestion.

Tyzine (Tetrahydrozoline Nasal Spray) Dose in Adults

Tyzine (Tetrahydrozoline Nasal Spray) Dose in the treatment of Nasal congestion:

• Intranasal: Instill 2 to 4 drops or 3 to 4 sprays of 0.1% solution into each nostril every 3 or 4 hourly as required. The minimum duration between two doses should be three hours.

Tyzine (Tetrahydrozoline Nasal Spray) Dose in Childrens

Tyzine (Tetrahydrozoline Nasal Spray) Dose in the treatment of Nasal congestion: Intranasal:

• Children 2-6 years:

  • Instill 2 or 3 drops of 0.05% solution into each nostril every 4 to 6 hours as needed. The duration between two doses should not be less than three hours.
• Children >6 years: Refer to adult dosing.

Pregnancy Risk Factor C

• It has not been studied in animal or human reproduction studies. It may be used with caution and if the benefits outweigh the risks.

Dose in Liver disease:

No dosage adjustments have been recommended by the manufacturer.

Dose in Liver disease:

No dosage adjustments have been recommended by the manufacturer.

Side Effects of Tyzine (Tetrahydrozoline Nasal Spray):

• Respiratory:

  • Sneezing
  • Stinging sensation of the nose

• Cardiovascular:

  • Hypertension
  • Palpitations
  • Tachycardia

• Central nervous system:

  • Headache

• Neuromuscular & skeletal:

  • Tremor

• Ophthalmic:

  • Blurred vision

Contraindications to Tyzine (Tetrahydrozoline Nasal Spray):

• Allergy reactions to tetrahydrozoline and any component of the formulation
• Children younger than 2 years old should not be exposed to the 0.05% solution.
• Children younger than six years old should avoid the 0.1% solution.

Warnings and precautions

• Somnolence

  • Drug overdose may result in drowsiness in children. 
  • Overdosed children may experience excessive sweating, hypotension and/or shock. 
  • To avoid side effects, the recommended dosage should not exceed.

• Cardiovascular disease

  • Sympathimetics should be avoided by patients with cardiovascular disease.

• Endocrine disorders:

  • Patients with endocrine conditions such as diabetes or hyperthyroidism, should be cautious when using the drug.

Tetrahydrozoline (nasal): Drug Interaction

Monitoring parameters:

• Monitor Blood pressure, heart rate, and response to treatment.

How to administer Tyzine (Tetrahydrozoline Nasal Spray)?

• It is administered intranasally.
• The patient should blow the nose and clean it before use.
• The tip of the spray should be inserted into the nostril while the other nostril is blocked.
• The medicine is sprayed into the nostril and the patient asked to keep breathing with the same nostril for a brief time.

Mechanism of action of Tyzine (Tetrahydrozoline Nasal Spray):

• It is a sympathomimetic medication that causes nasal vasoconstriction through stimulation of the alpha-adrenergic nerves in the nasal mucosa.

The beginning of actionDecongestant: 4-8 Hours

International Brands of Tetrahydrozoline Nasal Spray:

• Tyzine

Tetrahydrozoline Brand Names in Pakistan:

No Brands Available in Pakistan.