Brinzolamide decreases the formation of aqueous humor by inhibiting the enzyme carbonic anhydrase resulting in a reduction in the intraocular pressure. It is used for the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.

Brinzolamide Dose in Adults

Brinzolamide in the treatment of Elevated intraocular pressure:

• Instill one drop in the affected eyes three times a day.

Brinzolamide Dose in Childrens

Safety and efficacy of brinzolamide in children has not been established. 

Pregnancy Risk Factor C

• You should use it with caution, as adverse fetal events were observed in animal reproduction studies.

Brinzolamide use during breastfeeding:

• Because of possible adverse reactions in neonates, the manufacturer suggests that you continue to breastfeed or continue with the drug.

Brinzolamide Dose in Renal Disease:

• CrCl of 30 mL/minute or more:
  • The manufacturer has not recommended any dose adjustment.
• CrCl of less than 30 mL/minute:
  • Avoid its use as it has not been studied and the drug is primarily excreted by the kidneys.

Brinzolamide Dose in Liver Disease:

• The manufacturer has not recommended any dose adjustment in patients with liver disease.

Common Side Effects of Brinzolamide Include:

• Cardiovascular:
  • Hyperemia
• Central Nervous System:
  • Foreign Body Sensation of Eye
  • Headache
• Dermatologic:
  • Dermatitis
• Gastrointestinal:
  • Dysgeusia
• Ophthalmic:
  • Blurred Vision
  • Blepharitis
  • Eye Discharge
  • Eye Discomfort
  • Eye Pain
  • Eye Pruritus
  • Keratitis
  • Xerophthalmia
• Respiratory:
  • Rhinitis

Contraindication to Brinzolamide include:

• Allergy or intolerance to brinzolamide, any component of the formulation
• Allergies to sulfonamides
• Severe renal impairment, with a CrCl less than 30 mg/min
• Hyperchloremic acidosis

Warnings and Precautions

• Ophthalmic effects
  • It is possible for the vision to temporarily blurr.
  • This could lead to impairments in mental or physical abilities.
  • Patients who perform tasks that require mental alertness or those who drive heavy machinery or are prone to falls should be aware of the dangers.
• Sulfonamide"sulfa"Allergy:
  • Sulfa drugs, which contain a sulfonamide chemical compound group, can cause severe allergic reactions in patients who are allergic to them.
  • You should be cautious as cross-reactivity could occur.
  • Avoid it if you have had severe allergic reactions, such as Steven Johnson syndrome or TEN.
• Acute angle-closure glaucoma:
  • It has not been studied in acute angle-closure glaucoma.
• Corneal edema
  • Patients with low endothelial cells counts may experience corneal edema. This should be avoided.
• Renal impairment
  • Patients with severe renal impairment should not be given the drug.

Brinzolamide: Drug Interaction

Note: Drug Interaction Categories:

• Risk Factor C: Monitor When Using Combination
• Risk Factor D: Consider Treatment Modification
• Risk Factor X: Avoid Concomitant Use

Monitoring parameters:

• Monitor the intraocular pressure and regularly examine the eye.

How to administer Brinzolamide?

• Shake the ophthalmic solution well before use.
• Remove contact lenses before administering it and wait for 15 minutes before reinserting.
• If two or more drugs are to be used, they should be administered at least 10 minutes apart.
• The tip of the dispensing container should not touch the eye or the surrounding structures.

Mechanism of action of Brinzolamide:

• It decreases the formation of aqueous humor by inhibiting the enzyme carbonic anhydrase. 
• Reduction in aqueous humor production results in a reduction of intraocular pressure.
• It builds up in red blood cells, where it binds with the enzyme carbonic acidase. 

60% of the drug's content is protein-bound. It is converted to N-desethyl buzolamide, and excreted in the urine.

Interantional Brands of Brinzolamide:

• Azopt
• Azoptic
• Benozol
• Brinz
• Brinzo-Vision
• Brinzopt
• BrinzoQuin
• Ocubrin

Brinzolamide Brands in Pakistan: