Emedastine (Emadine) is a second-generation antihistamine that is used for ophthalmic use to relieve symptoms of allergic conjunctivitis.

Emedastine (Emadine) Uses:

• Allergic conjunctivitis:

  • It is used for the symptomatic relief of allergic conjunctivitis.

Emedastine (Emadine) Dose in Adults

Emedastine (Emadine) Dose for Allergic conjunctivitis:

• Ophthalmic:
  • Instill one drop in the affected eye up to four times a day.

Use in children:

Instill one drop in the affected eye up o four times a day.

Emedastine (Emadine) Pregnancy Risk Category: B

• Systemic absorption is very low after ophthalmic treatment.
• It has also not been shown to cause adverse fetal outcomes in animal research.
• If the drug is administered during pregnancy, there is no risk to fetal exposure.

Use during breastfeeding:

• It is unknown if the drug will be excreted into breastmilk.
• It is recommended that you use it with caution if you are breastfeeding.

Emadine Dose in Kidney disease:

• In the manufacturer's labeling adjustment in the dose has not been recommended.
• However, since absorption following ophthalmic instillation is minimal, dose adjustment is usually not required.

Emadine Dose in Liver disease:

• In the manufacturer's labeling, an adjustment in the dose has not been provided.
• However, since absorption is minimal following ophthalmic use, dose adjustment is not required.

Frequency not always defined.

Common Side Effects of Emedastine (Emadine):

• Central nervous system:

  • Headache

Less Common Side Effects of Emedastine (Emadine):

• Cardiovascular:

  • Hyperemia

• Central nervous system:

  • Abnormal dreams

• Dermatologic:

  • Dermatitis
  • Pruritus

• Gastrointestinal:

  • Dysgeusia

• Neuromuscular & skeletal:

  • Weakness

• Ophthalmic:

  • Blurred vision
  • Corneal infiltrates
  • Corneal staining
  • Keratitis
  • Lacrimation
  • Transient burning or stinging in the eyes
  • Xerophthalmia

• Respiratory:

  • Rhinitis
  • Sinusitis

Contraindications to Emedastine (Emadine):

Allergic reactions to the drug or any component of the formulation.

Monitoring parameters:

Not mentioned. However, monitor the response to the treatment. In case of worsening symptoms, consult a physician.

How to administer Emedastine (Emadine)?

• It is intended for ophthalmic use only. Before using the drug, wash hands.
• Avoid touching the tip of the dropper with the eyelids or other surfaces when using it to avoid contamination.
• Contact lenses should be removed before administering the drug.
• After instilling the drops, wait for about ten minutes before reinserting the contact lenses.
• Patients with red eyes should avoid wearing contact lenses

Mechanism of action of Emedastine (Emadine):

It is intended to be applied topically as a selective antagonist of the H-1 receptor histamines.

Absorption

• After ocular administration, there is very little.

Plasma half-life elimination

• After oral administration, it takes 3-4 hours 

International Brand Names of Emedastine:

• Emadine
• Daren
• Emeromin
• Remicut SR

Emedastine Brand Names in Pakistan: