Lacrisert (Hydroxypropyl Cellulose) lubricates the eyes and increases the tear breakdown time. It is used in the treatment of patients with dry eye syndrome.

Hydroxypropyl cellulose Uses:

• Moderate to severe dry eye syndromes:

  • It is used for the treatment of moderate to severe dry eye syndromes, including:
    • keratoconjunctivitis sicca (especially in patients with severe disease who remain symptomatic despite an adequate trial of artificial tear solutions);
    • Exposure keratitis;
    • Decreased corneal sensitivity, and
    • Recurrent corneal erosions

Hydroxypropyl Cellulose (Lacrisert) Dose in Adults

Hydroxypropyl Cellulose (Lacrisert) Dose in the treatment of moderate to severe dry eye syndromes:

• Ophthalmic:
  • Insert once daily into the inferior cul-de-sac beneath the base of the tarsus.
  • some patients may require twice-daily use.

Use in Children:

Refer to adult dosing.

Pregnancy Risk Category: N

• Hydroxypropylcellulose is biologically inert and cannot be metabolized. The drug was not absorbed by animals in animal reproduction studies after oral administration.
• It must be absorbed by the fetus and then pass through the placental barrier.
• It is safe to use during pregnancy and nursing.

Dose in Kidney disease:

• There are no dosage adjustments provided in the manufacturer’s labeling.
• However, an adjustment in the dose is not required due to low systemic absorption.

Dose in Liver disease:

• There are no dosage adjustments provided in the manufacturer’s labeling.
• However, an adjustment in the dose is unlikely due to low systemic absorption.

Side effects of Hydroxypropyl Cellulose (Lacrisert):

• Ophthalmic:

  • Blurred vision
  • Eye irritation
  • Eyelid edema

Contraindications to Hydroxypropyl Cellulose (Lacrisert):

Allergy reactions to hydroxypropylcellulose or any other component of the formulation

Warnings and precautions

• • Corneal abrasion:

    • It can cause corneal tear or abrasion if it is not properly placed in the eye.

  • Ophthalmic effects

    • It can cause temporary blurring of vision. It should be used with caution by those who drive or operate heavy machinery.
    • If blurred vision persists, or causing discomfort, the inserts can be removed.

Monitoring Parameters:

None mentioned. Monitor for a response to the treatment.

How to administer Hydroxypropyl Cellulose (Lacrisert)?

• Insert into the inferior cul-de-sac of the eyes beneath the base of the tarsus (not in apposition to the cornea nor beneath the eyelid at the level of the tarsal plate).

Mechanism of action of Hydroxypropyl Cellulose (Lacrisert):

• It thickens and stabilizes the precorneal tears film.
• This prolongs tear film breakdown time.
• It protects and lubricates the eyes.

Time of action:

• 24-hours maximum

Absorption:

• Not absorbed

Excretion:

• Feces

International Brand  Names of Hydroxypropyl cellulose:

• Lacrisert

Hydroxypropyl cellulose Brand Names in Pakistan:

No Brands Available in Pakistan.