Urogesic Blue contains Hyoscyamine, methenamine, methylene blue, and sodium phosphate. The combination of drugs is used to relieve bladder spasm and irritation during voiding after urologic procedures.

Urogesic-Blue (Hyoscyamine, methenamine, methylene blue, and sodium phosphate) Uses:

• Urinary tract symptoms:

  • It is used for the treatment of symptoms of irritative voiding.
  • It is also used as an antispasmodic for the relief of urinary tract symptoms caused by diagnostic procedures and for the relief of local symptoms of lower urinary tract infection like hypermotility.

Urogesic-Blue Dose in Adults

Urogesic-Blue Dose in the treatment of Urinary tract symptoms:

• Oral: One tablet four times daily.

Urogesic-Blue Dose in Childrens

Urogesic-Blue Dose in the treatment of Urinary tract symptoms:

• Children >6 years:

  • Oral: Dosage must be individualized.

Pregnancy Risk Factor C

• This combination has not been used in animal reproduction studies.
• Placental barriers are breached by methenamine and hyoscyamine.
• Data regarding the oral use of methylene blue in pregnancy is limited.

Use of hyoscyamine and methenamine during breastfeeding.

• Breastmilk can contain hyoscyamine or methenamine.
• It is recommended that nursing mothers use it with caution, according to the manufacturer.

Dose in Kidney Disease:

• There are no dosage adjustments provided in the manufacturer’s labeling.

Dose in Liver disease:

• There are no dosage adjustments provided in the manufacturer’s labeling.

Side effects of Urogesic-Blue:

• Also see hyoscyamine, methenamine, and methylene blue monographs.

• Cardiovascular:

  • Flushing
  • Rapid Pulse

• Central Nervous System:

  • Dizziness
  • Drowsiness

• Gastrointestinal:

  • Fecal Discoloration (Blue To Blue-Green)
  • Nausea
  • Vomiting
  • Xerostomia

• Genitourinary:

  • Acute Urinary Retention.
  • Difficulty In Micturition.
  • Urine Discoloration (Blue To Blue-Green).

• Hypersensitivity:

  • Hypersensitivity Reaction (Rare)

• Ophthalmic:

  • Blurred Vision.

• Respiratory:

  • Dyspnea.

Contraindications to Urogesic-Blue (Hyoscyamine, methenamine, methylene blue, and sodium phosphate):

• Allergy reactions to hyoscyamine or methenamine, or any component in the formulation.

Warnings and precautions

• Belladonna alkaloid allergy:

  • Patients who have a history of intolerance or intolerance to belladonna and alkaloids should be cautious.

• Blurred vision

  • Treatment should be stopped if blurred vision occurs.

• Dizziness:

  • If dizziness develops, discontinue treatment.

• Salicylate allergy

  • Patients who have a history of intolerance should be cautious when using salicylates.

• Tachycardia

  • If tachycardia develops, discontinue use immediately.

• Cardiovascular disease

  • It should be used with caution for patients with cardiovascular disease like congestive heart disease, heart failure, heart disease, cardiac arrhythmias, and mitralstenosis.

• Gastrointestinal Disease:

  • Patients suffering from gastrointestinal obstruction or gastric ulcers must be cautious when taking the drug.

• Glaucoma:

  • Patients suffering from glaucoma or elevated intraocular pressure need to be cautious.

• Myasthenia gravis:

  • Patients suffering from myasthenia gravis must be cautious when taking the drug.

• Obstructive Uropathy:

  • Patients with obstructive urinary problems such as prostatic hyperplasia or bladder neck obstruction should be cautious as it can lead to urinary retention.

Monitoring parameters:

• Monitor Urinary tract symptoms.

How to administer Urogesic-Blue (Hyoscyamine, methenamine, methylene blue, and sodium phosphate)?

It is administered orally with a plenty amount of fluid.

Mechanism of action of Hyoscyamine, methenamine, methylene blue, and sodium phosphate (Urogesic-Blue):

Hyoscyamine:

• Parasympatholytic drugs that relax the smooth muscles and produce an antispasmodic effects.

Methenamine:

• Hydrolysis of methenamine in acidic urine results in formaldehyde. This has both bacteriostatic and bactericidal properties.

Methylene blue:

• Methylene blue, which is a weak antiseptic solution that can be used primarily as a dye, is also known.

Monobasic sodium phosphate:

• Monobasic sodium phosphate maintains an acid pH in the urine which is necessary for the degradation of methenamine.

See individual agents.

International Brand Names of Hyoscyamine, methenamine, methylene blue, and sodium phosphate:

• Indiomin MB
• ME/NaPhos/MB/Hyo1
• Uro-BLUE
• Urogesic-Blue
• Urolet MB
• UTA

Hyoscyamine, methenamine, methylene blue, and sodium phosphate Brand Names in Pakistan:

No Brands Available in Pakistan.