Lumigan (Bimatoprost) is a synthetic analog of prostaglandin that increases the outflow of aqueous humor resulting in a reduction in the intraocular pressure. It is used to treat the following conditions:

• For the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension (Lumigan, Vistitan).

• Treatment for the growth of eyelashes (Latisse).

Lumigan (Bimatoprost) Dose in Adults

Lumigan use in the treatment of  Elevated intraocular pressure:

• Instill one drop into the affected eye once a day in the evening.
• With concomitant administration of other ophthalmic solutions, separate administration by at least five minutes.
• More than once a day administration is not recommended.

Use in the treatment for the growth of eyelashes (Latisse):

• For Topical Ophthalmic use:
• Place one drop on the applicator and apply evenly along the skin of the upper eyelid at the base of eyelashes once a day at bedtime
• Use a clean applicator for the second eye.

Lumigan (Bimatoprost) Dose in Childrens

Use in the treatment of raised intraocular pressure (Lumigan):

• Adolescents older than 16 years:
  • Refer to adult dosing.

Use in the treatment for the growth eyelashes (Latisse):

• Children older than 5 years and Adolescents:
  • Refer to adult dosing.

Pregnancy Risk Factor: C

• Pregnancy has not been associated with adverse maternal and fetal effects.
• The lowest dose is best when used with punctual occlusion.

Bimatoprost use during breastfeeding:

• It is unknown if bimatoprost can be absorbed into breastmilk.
• The manufacturer weighs the benefits for the mother and the risks for the fetus.

Lumigan (Bimatoprost) Dose in Renal Disease:

• Dose adjustment in patients with kidney disease is not recommended by the manufacturer.

Lumigan (Bimatoprost) Dose in Liver Disease:

•  Dose adjustment in patients with liver disease is not recommended by the manufacturer. 

Common Side Effects of Lumigan (Bimatoprost) Include:

• Dermatologic:
  • Increased growth in the number of eyelashes
• Ophthalmic:
  • Conjunctival hyperemia
  • Eye pruritus

Less Common Side Effects of Bimatoprost Include:

• Central nervous system:
  • Headache
  • Foreign body sensation of eye
• Dermatologic:
  • Erythema of eyelid
  • Hyperpigmentation of eyelashes
  • Local skin hyperpigmentation
• Endocrine & metabolic:
  • Hirsutism
• Hepatic:
  • Abnormal hepatic function tests
• Infection:
  • Infection
• Neuromuscular & skeletal:
  • Asthenia
• Ophthalmic:
  • Dry eye syndrome
  • Eye Irritation
  • Allergic Conjunctivitis
  • Asthenopia
  • Blepharitis
  • Burning Sensation of Eyes
  • Cataract
  • Conjunctival Edema
  • Conjunctival Hemorrhage
  • Eye Discharge
  • Eye Pain
  • Iris Hyperpigmentation
  • Lacrimation
  • Photophobia
  • Superficial Punctate Keratitis
  • Visual Disturbance

Contraindication to Bimatoprost Include:

• Allergy reactions to bimatoprost and any component of this formulation

Warnings and Precautions

• Bacterial Keratitis
  • Inadvertent contamination may lead to bacterial keratitis.
• Ocular effects
  • Permanent brownish pigmentation may occur in the iris, eyelid skin, periorbital tissues, and eyelashes.
• Ocular inflammation:
  • Patients with active intraocular inflammation or uveitis should be cautious as this may worsen the condition.
• Ocular disease:
  • The use of it in patients with angle-closure, Neovascular Glaucoma, and Inflammatory Glaucoma has not yet been investigated.
  • Avoid aphakic patients and pseudophakics with a damaged posterior lens capsule.

Bimatoprost: Drug Interaction

How to administer Bimatoprost?

• Latisse:

  • Before application, clean face, remove make-up and contact lenses.
  • Apply the medicine with the sterile applicator provided and blot any excess solution with a tissue.
  • Do not apply to the lower eyelash line.
  • The applicators should not be reused. A new applicator should b used for the other eye.
  • More than once application is not recommended and will not result in the rapid growth of the eyelashes.
  • Contact lenses may be inserted after 15 minutes of administering the drug.

• Lumigan, Vistitan

  • It may be used with other medicines that lower the intraocular pressure.
  • Contact lenses should be reinserted after 15 minutes of administering the drug.
  • With concomitant administration of other ophthalmic solutions, it should be separated by an interval of 5 minutes.

Mechanism of action of Lumigan (Bimatoprost):

• It is a synthetic analog to prostaglandin. It increases the flow of aqueous humor, causing a decrease in intraocular pressure.
• This causes the growth of eyelashes, increasing the percentage and duration of hair growth.

It has beenThe beginning of actionapproximately 4 hours.

 peak effectIt can be seen within 8 to 12 hours. 88% of the drug can be absorbed. protein-bound. It isMetabolizedAfter reaching the systemic circulation, the process of oxidation or glucuronidation takes place.

The intravenous administration of the medication is completed.half-life eliminationIt takes approximately 45 minutes to achieve peak effects.

The peak effect can be seen in around 10 minutes. It isexcretedPrimarily in the urine

International Brands of Lumigan (Bimatoprost):

• Latisse
• Lumigan
• Lumigan RC
• Vistitan
• Bimagan
• Bimaprost
• Bimast
• Bimat
• Bimato-Vision
• Bimatoswix
• Bimican
• Careprost
• Glamigan
• Glash Vista
• Lumiprox
• Matrocond
• Sturiban
• Vizibim

Bimatoprost brands in Pakistan: