Miconazole (Oravig) Oral tablet is used to treat mild candidal infections of the oral cavity and pharynx.

Oral Miconazole Uses:

• for the therapeutic treatment of oropharyngeal candidiasis, this drug can be used

Oral Miconazole Dose in Adults:

Treatment of mild oropharyngeal candidiasis with an oral dose of miconazole (Oravig)

• Buccal tablet:
  • On a daily basis, a single tablet of 50 mg is applied to the canine fossa for 1 to 2 weeks.

Dose in Children:

Refer to adults' dosing.

Pregnancy Risk Factor C

• After buccal application, there is very little systemic absorption. 
• Nevertheless, episodes of adverse pregnancies have been seen in animal reproduction analysis.

Use during breastfeeding:

• It is unknown whether the drug will be excreted into breastmilk. 
• Systemic absorption after the buccal application is also minimal. 
• It is recommended that breastfeeding mothers avoid using it.

Dose in Kidney Disease:

No dosage adjustment is necessary.

Dose in Liver disease:

There are no dosage adjustments provided in the manufacturer’s labeling. Use with caution.

Common Side Effects of Miconazole (Oravig):

• Local:

  • Includes application site reaction
    • Local discomfort
    • Local pain
    • Oral mucosa ulcer
    • Localized edema
    • Toothache
    • Local pruritus
    • Localized burning
    • Glossalgia

Less Common Side Effects of Miconazole (Oravig):

• Gastrointestinal:

  • Dysgeusia
  • Vomiting
  • Gastroenteritis
  • Sore throat
  • Oral discomfort
  • Xerostomia
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Ageusia
•  

• Central nervous system:

  • Headache
  • Fatigue
  • Pain

• Respiratory:

  • Cough
  • Upper respiratory tract infection

• Endocrine & metabolic:

  • Increased gamma-glutamyl transferase

• Dermatologic:

  • Pruritus

• Hematologic & oncologic:

  • Anemia
  • Lymphocytopenia
  • Neutropenia

Contraindications to Miconazole (Oravig):

Hypersensitivity to the formulation's ingredients, including milk protein concentrates and miconazole.

Warnings and precautions

• Hypersensitivity reactions

  • There have been reports of allergic reactions, including anaphylactic reactions.
  • Cross-sensitivity reactions can occur, so patients who have had an allergic reaction to any azole medication should be cautious.

• Hepatic impairment

  • It has minimal systemic absorption after buccal application. However, patients with impaired liver function should not use it.

Miconazole (oral): Drug Interaction

Monitoring Parameters:

None mentioned. Monitor the response to treatment.

How to administer Miconazole (Oravig)?

Oral:

• In cases of mild oropharyngeal candidiasis, oral pills are utilized.
• After cleaning teeth in the morning, it is administered orally.
• Drying the hands is necessary before inserting the pills.
• Place the tablet's two sides on the gum tissue in the area above the incisor tooth.
• For at least 30 seconds, the tablet is held over the top lip with mild pressure.
• It could be more pleasant to place the rounded side of the tablet against the gum.
• For every application, switch which side of the mouth you're using.
• The pills must not be eaten, crushed, or ingested.
• It is best to refrain from chewing gum while the pill is in place.
• The pill should be repositioned if it does not cling to the gums correctly or comes loose within six hours after administration.
• If the tablet doesn't stick to the gum, it can be adjusted.
• A new tablet should be used and the patient should be instructed to drink a cup of water if the tablet is consumed within six hours after administration (once only).
• The dose should not be repeated if the pill is ingested or comes off after six hours of application; instead, a fresh tablet may be taken at the subsequent scheduled time.

Mechanism of action of Oral Miconazole (Oravig):

It causes damage to fungal cell walls and inhibits the synthesis ergosterol. This increases the permeability of cells, resulting in nutrients leaking from fungal cells.

Duration: Buccal adhesion:

• 15 hours

Absorption:

• Minimal

International Brand Names of Oral Miconazole:

• Oravig
• A-Migel
• Brentan
• Daktar
• Daktarin
• Daktarin Oral Gel
• Decozole Oral Gel
• Fungisidin
• Loramyc
• Micoral
• Micotar Mundgel
• Mikozal
• Mycoheal
• Oramic
• Oravi Mucoadhesive tablets
• Rojazol
• Tibozole

Miconazole Brand Names in Pakistan: