Topical corticosteroids, such as mometasone furoate (Elocon), are used to treat skin disorders like eczema that respond to them.

Mometasone Furoate Uses:

• Corticosteroid-responsive dermatoses:

  • It is used to relieve the inflammatory and itchy symptoms of dermatoses that respond to corticosteroids. It is a topical corticosteroid of medium strength.

Read: Topical Hydrocortisone Cream, Ointment, Lotion Uses & Brands

Mometasone Furoate Dose in Adults:

Mometasone Furoate Dose in the treatment of Corticosteroid-responsive dermatoses:

• Topical: Avoid using occlusive dressings and apply it sparingly. When control is attained, therapy should be stopped. If progress is not noticed after two weeks, it may be time to reevaluate the diagnosis.
• Cream, ointment: Once every day, apply a thin coating to the afflicted region. 
  Lotion, solution: Once every day, apply a few drops to the afflicted region.

Mometasone Furoate Dose in Children:

Note: Withhold treatment until you've gained control. If there is no improvement after two weeks, reevaluate the diagnosis.

Mometasone Furoate Dose in the treatment of Corticosteroid-responsive dermatoses:

• Lotion, solution:

  • Children ≥12 years and Adolescents: Topical: Apply a few drops to the affected area once a day. Massage lightly into the skin

• Cream, ointment:

  • Children older than 2 years and teenagers: Topical: Apply a thin film to the affected area once a day. Avoid using it for over 3 weeks in pediatric patients.

Pregnancy Risk Factor C

• The systemic bioavailability for topical corticosteroids can vary. It is dependent on skin integrity, use of occlusion, and other factors. It may also be affected by the trimester.
• The danger to a woman's pregnancy from topical corticosteroids is negligible.
• High doses of topical products or potent ones may increase the risk of low birth weight babies.
• Pregnant females should only use mild-to-moderate potency topical corticosteroids. Large amounts of steroids or prolonged use are not recommended.
• Animal reproduction studies have seen adverse events.
• Avoid areas with high levels of percutaneous absorption.
• Topical corticosteroids may make stretch marks more likely to appear.

Mometasone use during breastfeeding:

• It is unknown if adequate amounts of mometasone have been absorbed by topical administration to detectable amounts in breast milk. Limited data are available.
• Breast milk contains systemic corticosteroids. While literature suggests caution, topical corticosteroids can be used in breastfeeding females.
• Until breastfeeding stops, do not apply any topical corticosteroids directly to the breasts. A high-potency topical corticosteroid applied to the nipple caused hypertension in a breastfed baby.

Dose in Kidney Disease:

There are no dosage adjustments needed for renal impairment.

Dose in Liver disease:

There are no dosage adjustments recommended for hepatic impairment.

Side Effects of Mometasone Furoate:

• Hematologic & Oncologic:

  • Bruise

• Central Nervous System:

  • Paresthesia

• Dermatologic:

  • Telangiectasia
  • Dermatologic Disorders
  • Dyschromia
  • Taut And Shiny Skin
  • Folliculitis
  • Bacterial Skin Infection
  • Epidermal Thinning

• Local:

  • Application Site Burning
  • Application Site Pruritus

• Gastrointestinal:

  • Xerostomia

• Endocrine & Metabolic:

  • Decreased Cortisol
  • Endocrine Disease

Frequency of side effects not defined:

• Dermatologic:

  • Furunculosis
  • Skin Atrophy
  • Acne Rosacea
  • Stinging Of The Skin

• Central Nervous System:

  • Tingling Of Skin

Contraindications to Mometasone Furoate:

An allergy to mometasone furoate or any other ingredient in this formulation is a contraindication. Data on corticosteroids' cross-reactivity with allergens are few.
Cross-sensitivity could not always be ruled out because of parallels in pharmacologic action.

Labeling in Canada: Additional precautions not included in the US labeling

• Ophthalmic use
• It can be used with occlusive dressings
• Bacterial, fungal, or viral skin infections, such as varicella or herpes. parasitic diseases. symptoms of TB on the skin. infections with cysts. skin rashes following immunizations.

Warnings and precautions

• Suppression of the adrenals:

  • An adrenal crisis might result from the suppression of the HPA axis.
  • For example, When taken in high doses for long periods of time or by younger people, it may lead to hypercortisolism or inhibition of the hypothalamic-pituitary-adrenal (HPA) axis.

• Contact dermatitis:

  • Allergic contact dermatitis is easily diagnosed. Instead of clinical aggravation, the failure of healing is frequently used to diagnose it. If irritation occurs, discontinue using it and seek medical attention.

• Immunosuppression:

  • Long-term use can lead to fungal and bacterial superinfections. 
  • If the dermatological infection persists, even with appropriate antimicrobial treatment, stop using it.

• Ocular effects

  • Pay attention to any ocular changes. Avoid eye contact.
  • Mometasone is one example of a topical corticosteroid that can raise the risk of glaucoma and subcapsular cataracts in the posterior eye.

• Systemic effects

  • The use of occlusive dressings or the application to heavily covered areas can increase absorption.
  • Percutaneous absorption of topical corticosteroids may be possible.
  • Hyperglycemia or Cushing's syndrome may result from the absorption of topical corticosteroids. 

Mometasone (topical): Drug Interaction

Monitoring parameters:

• Response to treatment.
• Long-term suppression of the adrenal glands (ACTH stimulation test, morning plasma cortisol test, urinary free cortisol test should be done).
• Ocular changes

How to administer Mometasone Furoate?

• Apply with caution. Abstain from a mucous membrane. The manufacturer's warning labels advise against using it near your face, underarms, groin, or eyes (including the diaper area).
• Do not wrap, cover, or bandage the affected area.
• Cream, ointment:
  • Apply a thin layer onto the affected region
• Lotion, solution:
  • To remove the medication, gently massage the affected area after applying a few drops of the medication.

Mechanism of action of Mometasone Furoate:

• Reduced generation, release, and activity of endogenous chemical mediators may be achieved by stimulating phospholipase A inhibitory protein (lipocortins) and subsequently inhibiting the release of arachidonic acid (kinins and histamines, liposomal enzymes, and prostaglandins).
• A medication with intermediate potency is mometasone.
• Anti-inflammatory, anti-pruritic, and vasoconstrictive are all properties of topical corticosteroids.

Absorption:

• Lotion, ointment, and solution: 0.7% (increased due to inflammation).
• Cream: 0.4% (increased due to inflammation).

International Brand Names of Mometasone Furoate:

• Elocon
• Allerta Dermatec
• Allerzone
• Avocom
• Borgasone
• Cortimon
• Dermacortine
• Dermome
• Dermotasone
• Dermovel
• Ecural
• Eczaderm
• Elica
• Elicort
• Elisone
• Elna
• Elocom
• Elocon
• Elocon Cream
• Elocon Ointment
• Elocortin
• Elomet
• Eloskin
• Eloson
• Elosone
• Flogocort
• Inpura
• Intercon
• Konex
• Lavelia Lotion
• Loksin
• Lomeane
• Mefurosan
• Melocon
• Meloderm
• Melomet
• Mesone
• Metaz
• Metson
• Mezo
• Mofulex
• Mofuroate
• Momate
• Momecort
• Momed
• Momederm
• Momet
• Monovel
• Moricort
• Mosone
• Motaderm
• Moteson
• Mtaz
• Novasone Cream
• Novasone Lotion
• Novasone Ointment
• Soneta
• Suqi
• Topcort
• Vizomet
• Zatamil
• Zynovate

Mometasone Furoate Brand Names in Pakistan: