Ofloxacin eye drops and eye ointment are used to treat bacterial infections of the eye caused by susceptible bacterial organisms.

Ofloxacin eye drops and Ointment Uses:

• Bacterial conjunctivitis:

  • Used or treatment of bacterial conjunctivitis caused by Staphylococcus aureus, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus epidermidis, , Enterobacter cloacae, Haemophilus influenzae and Pseudomonas aeruginosa.

• Corneal ulcer:

  • Treatment of corneal ulcers caused by S.aureus, S.epidermidis, S.pneumoniae, P.aeruginosa, Serratia marcescens & Cutibacterium acnes.

Ofloxacin eye drops Dose in Adults

Ofloxacin eye drops Dose in the treatment of Bacterial conjunctivitis:

• Ophthalmic:
• In affected eye(s), instill 1 to 2 drops every 2 to 4 hours for the first 2 days, then instill 1 to 2 drops 4 times every day for an additional 5 days.

Ofloxacin eye drops Dose in the treatment of Corneal ulcer:

• Ophthalmic:
• in the affected eye(s), instill 1 to 2 drops every half an hour while awake and every 4 to 6 hours after retiring for the first 2 days.
• Beginning on day 3, instill 1 to 2 drops every hour while awake for 4 to 6 additional days.
• Thereafter, 1-2 drops 4 times every time until clinical cure.

Ofloxacin eye drops Dose in Childrens

Ofloxacin eye drops dose in the treatment of Bacterial conjunctivitis:

• Children and Adolescents:

  • Initial:
  • In affected eye(s), instill 1 to 2 drops every 2-4 hours for the first 2 days (Days 1 and 2).
  • Then, for an additional 5 days instill 1-2 drops 4 times every day (Days 3 through 7)

Ofloxacin Eye Drops dose in the treatment of Corneal ulcer:

• Children and Adolescents:

  • Initial:

  • In affected eye(s), instill 1 to 2 drops every half hour while awake and every 4-6 hours at night for the first 2 days (Days 1 and 2).
  • Then, for 4-6 additional days, instill 1-2 drops every hour while awake (Days 3 through 7 to 9).
  • Thereafter, 1 to 2 drops 4 times daily until the clinical cure is achieved

Pregnancy Risk Factor C

• Some adverse events were observed in animal reproduction studies.
• Orally administered Ofloxacin crosses into the placenta (Giamarellou 1989).
• Topical application of the drops of ophthalmic medication is less effective than oral doses.
• To reduce potential exposure to the foetus, pregnant women should use the minimum effective dose of ophthalmic agent.
• This is combined with punctual occlusion for 3-5 minutes after application.

Ofloxacin eye drops use during breastfeeding:

• When administered orally, ofloxacin can enter breast milk.
• It is unknown if ofloxacin is found in breast milk after ophthalmic applications.
• Manufacturer recommends that you decide whether to stop nursing or discontinue using the drug.
• This is taking into consideration the importance of mother's treatment, as there are potential adverse reactions in nursing infants.

Dose in Kidney Disease:

• In the manufacturer’s labeling, there are no dosage adjustments provided.
• However, dosage adjustment unlikely due to low systemic absorption.

Ofloxacin eye drops Dose in Liver Disease:

• In the manufacturer’s labeling, there are no dosage adjustments provided.
• However, dosage adjustment unlikely due to low systemic absorption.

Side effects of Ofloxacin Eye Drops and Ointment:

• Central Nervous System:

  • Dizziness
  • Foreign Body Sensation Of Eye

• Gastrointestinal:

  • Nausea

• Ophthalmic:

  • Blurred Vision
  • Burning Sensation Of Eyes
  • Conjunctivitis (Chemical)
  • Eye Discomfort
  • Eye Pain
  • Eye Pruritus
  • Eye Redness
  • Keratitis (Chemical)
  • Lacrimation
  • Photophobia
  • Stinging Of Eyes
  • Swelling Of Eye
  • Xerophthalmia

Contraindication to Ofloxacin Eye Drops and Ointment:

• Hypersensitivity to ofloxacin or other quinolones or any component in the formulation

Warnings and precautions

• Hypersensitivity reactions

  • Anaphylaxis, anaphylactic shock, and rare severe hypersensitivity reactions (some fatal) have been reported with systemic quinolone treatment (some after the first dose).
  • Some reactions can be accompanied by angioedema (laryngeal pharyngeal or facial edema), cardiovascular failure, dyspnea and loss of consciousness. Stop using the treatment if you experience an allergic reaction.

• Superinfection

  • Long-term use can lead to fungal and bacterial superinfections.
  • If superinfection is suspected, you can initiate appropriate alternative treatment.

• Tendon rupture and inflammation

  • Tendon inflammation and rupture have been reported after taking systemic quinolone anti-biotics.
  • The exposure following ophthalmic administration will be significantly lower than that after systemic therapy.
  • Stop immediately if you feel any tendon inflammation or pain.

Monitoring parameters:

Monitor response to treatment and superimposed fungal infections in chronic users.

How to administer Ofloxacin eye drops and ointment?

• Use only for ophthalmic, not for injection.
• Avoid touching fingers, the tip of the applicator to the eye, or other surfaces.

Mechanism of action of Ofloxacin (Ophthalmic):

• Ofloxacin acts as a DNA gyrase inhibitor.
• DNA gyrase, an essential bacterial enzyme, is responsible for maintaining the DNA's superhelical structure.
• DNA gyrase is essential for DNA transcription, replication, recombination and transposition.

Absorption:

• After ophthalmic instillation, only small amounts are absorbed systemically.

Excretion:

• Urine

International Brands of Ofloxacin (Ophthalmic):

• Ocuflox
• APO-Ofloxacin
• Ocuflox
• PMS-Ofloxacin
• SANDOZ Ofloxacin
• Aflacin
• Dong Kang Ming
• Exocin
• Exocine
• Floxal
• Floxedol
• Floxsal
• Inoflox
• Ocuflox
• Oflacin
• Oflovid
• Oflox
• Ofloxin
• Ofus
• Ofven
• Operan
• Optiflox
• Otoflox
• Oxacin
• Poenflox
• Quinovid
• Tarivid
• Telbit
• Trafloxal
• Uniflox
• Vista
• Ximex Koniflox

Ofloxacin Eye Drops and Ointments Brand Names in Pakistan: