Plasma Protein Fraction is a relatively less purified form of plasma proteins derived from human plasma that contains albumin and plasma globulins. It is usually given to patients with hypotension and shock as a result of plasma leakage.

Plasma protein fraction Uses:

• Shock:
  • It is indicated for the treatment of shock resulting from loss of plasma fluids and proteins (as in shock following severe burns, crush injuries, and abdominal emergencies).
  • It may be administered to patients with shock secondary to hemorrhage.

Read: Immune globulins Injection

Plasma Protein Fraction Dose in Adults

Plasma Protein Fraction during Shock:

• The usual minimum dose is 250 to 500 mL (12.5 to 25 g of protein) intravenously;
• Adjust the dose based on the clinical response.

Biseko use in Children:

It is usually administered in a dose of 1 - 2 ml/kg body weight.   

Pregnancy Risk Factor C

• There have never been any studies on human or animal pregnancies.
• It is best to avoid volume expansion in pregnancy unless it is strongly advised.

Dose in Kidney Disease:

There are no dosage adjustments provided in the manufacturer's labeling.   

Dose in Liver disease:

There are no dosage adjustments provided in the manufacturer's labeling.   

Side effects of Plasma Protein Fraction:

• Cardiovascular:
  • Edema
  • Flushing
  • Hypotension (related to rate of infusion)
• Central nervous system:
  • Headache
• Dermatologic:
  • Urticaria
• Gastrointestinal:
  • Nausea
• Neuromuscular & skeletal:
  • Back pain
• Respiratory:
  • Pulmonary edema

Contraindications to Plasma protein Fraction:

• Hypersensitivity to plasma proteins and any component of the formulation
• Patients receiving cardiopulmonary bypass
• Severe anemia
• heart failure;
• An increase in blood volume

Warnings and precautions

• Hypotension
  • Hypotension may occur when intravenous injections are given rapidly.
  • This may lead to the need for temporary withholding or decreasing the rate of infusion.

Monitoring parameters:

• Blood pressure,
• pulse,
• pulmonary exam

How to administer Plasma protein fraction?

• It is available for IV administration only.
• The infusion must be administered within four hours of preparing it.
• Rapid infusions should be avoided to prevent volume overload.
• Rapid infusions (exceeding 10 ml/minute) may result in hypotension.
• The rate of infusion must be reduced to avoid hypotension.   

Mechanism of action of Plasma protein Fraction:

It is derived from human plasma to increase blood volume.

Duration:

• Up to 48 hours

International Brand Names of Plasma protein fraction:

• Plasmanate
• Bioplasma FDP
• Biseko
• Plasma Proteinlosung 5%
• Plasmanate
• Plasmatein
• PPS

Plasma protein fraction Brand Names in Pakistan: