Tetrahydrozoline Eye Drops - Uses, Dose, MOA, Brands, Side effects

Tetrahydrozoline Eye Drops is a sympathomimetic drug that causes ocular arteriolar constriction. It is used to treat minor symptoms related to eye allergies.

Tetrahydrozoline eye drops uses:

  • Ocular decongestant:

    • It is used to relieve minor symptoms associated with ocular allergies such as redness of the eye, eye irritation, burning, and discomfort from dryness of the eyes as caused by exposure to sun and wind.

Tetrahydrozoline Eye Drops Dose in Adults

Tetrahydrozoline Eye Drops Dose as an ocular decongestant:

  • Ophthalmic: Instill 1 to 2 drops in the affected eye every six hourly (up to 4 times a day).

Tetrahydrozoline Eye Drops Dose in Childrens

Dose as an ocular decongestant (Visine products only):

  • Children ≥6 years, and Adolescents:

    • Ophthalmic: Refer to adult dosing.

Pregnancy Category: N (not assigned)

  • Data are limited regarding its use in pregnancy and lactation.
  • It should be used during pregnancy if the benefits outweigh the risks and unless advised by a healthcare provider, it should not be used.

Dose in Kidney Disease:

There are no dosage adjustments provided in the manufacturer’s labeling.

Dose in Liver disease:

There are no dosage adjustments provided in the manufacturer’s labeling.

Side effects of Tetrahydrozoline Eye Drops:

  • Cardiovascular:

    • Hypertension
    • Palpitations
    • Tachycardia
  • Central Nervous System:

    • Headache
    • Transient Burning Or Stinging In The Eyes
  • Neuromuscular & Skeletal:

    • Tremor
  • Ophthalmic:

    • Blurred Vision

Contraindications to Tetrahydrozoline Eye Drops:

  • Cross-reactivity between ophthalmic sympathomimetics and ophthalmic sympathomimetics has been limited. 
  • Cross-sensitivity is possible due to structural and pharmacological similarities. Patients who are allergic to any other sympathomimetics should be avoided.

Warnings and precautions

  • Cardiovascular disease

    • Patients suffering from cardiovascular disease should be advised to take sympathomimetic medications with caution.
  • Diabetes:

    • Use caution in diabetic patients.
  • Glaucoma:

    • Patients suffering from narrow-angle glaucoma need to be cautious.
  • Hyperthyroidism:

    • Patients with hyperthyroidism should not take any sympathomimetic medications.

Monitoring Parameters:

None mentioned.

How to administer Tetrahydrozoline Eye Drops?

  • It is intended for ocular (in eyes) use only.
  • Before instilling the eye drops, wash hands.
  • Avoid touching the tip of the dropper or the tip to the surrounding surfaces including the eyes, eyelids, and eyelashes.
  • The contact lenses should be removed when instilling the eye drops.
  • Wait for at least ten minutes after instilling the drops before inserting the contact lenses. If the eyes are red, avoid using contact lenses.

Mechanism of action of Tetrahydrozoline Eye Drops:

  • It is a sympathomimetic drug that acts by causing the arterioles in the conjunctive to constrict.
  • This results in a decongestant effect and improvement in allergic symptoms.

International Brand Names of Tetrahydrozoline:

  • Eye Drops
  • GoodSense Eye Drops
  • Opti-Clear
  • Visine Advanced Relief
  • Allersine
  • Apiallerg
  • Azoline
  • Bano Ocular
  • Berberil N
  • Berberil-N
  • Eye Clear
  • Eye Relief
  • Eye-Visol
  • Insto
  • Ivysine
  • Murine Plus
  • Murine Sore Eyes
  • Oftan Starine
  • Ophtal
  • Optispring
  • Optizoline
  • Santo
  • Stilla drops
  • Tetzoline
  • Tyzine
  • Vasopos
  • Visina
  • Visine
  • Visine Advanced
  • Visine Advanced Relief
  • Visine Classic
  • Visine Clear
  • Visine Original Eye Drops
  • Vispring
  • Visubril

Tetrahydrozoline Brand Names in Pakistan:

Tetrahydrozoline HCl Eye Drops 0.05 %w/v in Pakistan

Octilia Neo Medix

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