Alomide (Lodoxamide tromethamine) is a mast cells stabilizer that inhibits the immediate type of hypersensitivity reactions. It is used as eye drops for the treatment of patients with keratitis and keratoconjunctivitis.

Lodoxamide tromethamine Uses:

• Ocular disorders:

  • It is used for the Treatment of ocular disorders such as vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.

Lodoxamide tromethamine (Alomide) Dose in Adults:

Lodoxamide tromethamine (Alomide) Dose in the treatment of Ocular disorders:

• Ophthalmic: Instill 1 to 2 drops in each affected eye 4 times a day.

Use in Children:

Refer to adults dosing.

Pregnancy Category: B

• In animal reproduction studies, adverse fetal outcomes following oral administration have not been observed.
• After ophthalmic administration, the systemic level of lodoxamide is lower than that required for detection.

Use of Lodoxamide tromethamine during breastfeeding

• It is unknown if lodoxamide can be found in breast milk.
• Lodoxamide should not be administered to nursing mothers without caution, according to the manufacturer.

Dose in Kidney Disease:

• There are no dosage adjustments provided in the manufacturer's labeling.
• However, since minimal systemic absorption occurs, dosage adjustment is not required.

Dose in Liver disease:

• There are no dosage adjustments provided in the manufacturer's labeling.
• However, since minimal systemic absorption occurs, dosage adjustment is not required.

Common Side Effects of Lodoxamide tromethamine (Alomide):

• Ophthalmic:

  • Burning sensation of eyes (transient)
  • Eye discomfort (transient)
  • Stinging of eyes (transient)

Less Common Side Effects of Lodoxamide tromethamine:

• Central nervous system:

  • Foreign body sensation of eye
  • Headache

• Ophthalmic:

  • Blurred vision
  • Crystalline eye deposits
  • Eye pruritus
  • Lacrimation
  • Ocular hyperemia
  • Ocular edema
  • Xerophthalmia

Contraindications to Lodoxamide tromethamine (Alomide):

Allergy to lodoxamide and any other component of the formulation

Warnings and precautions

• Irritation

  • Instillation may cause discomfort, burning, or stinging.

• Ocular effects

  • Blurred vision and other visual disturbances can occur. However, they are usually temporary.
  • Patients should wait until their vision is clear before operating machinery or driving.

Monitoring Parameters:

None mentioned. Monitor the response to treatement.

How to administer Lodoxamide tromethamine (Alomide)?

• It is intended for topical ophthalmic use only, not for injection.
• Wash hands before use. Avoid contamination by not touching the tip of the dropper to the eyelids, eyes, or other surfaces when placing the eye drops.
• Remove contact lenses before instilling the drops and wait for 15 minutes or longer before reinserting the lenses.

Mechanism of action of Lodoxamide tromethamine (Alomide):

• It acts as a mast cell stabiliser and inhibits in vivo type 1 immediate hypersensitivity reactions. 
• It reduces cutaneous vascular permeability in response to IgE or antigen-mediated reactions, as is the case with type 1 immediate hypersensitivity reactions.

Absorption

• The effects of topical administration are negligible.

Half-life elimination:

• 8.5 hours

Excretion:

• Urine

International Brand Names of Lodoxamide tromethamine:

• Alomide
• Alconmide
• Almide
• Lomide

Lodoxamide tromethamine Brand Names in Pakistan: