Flavoxate (Urispas) is an antispasmodic drug that is used to relieve lower urinary tract symptoms such as urgency, frequency, nocturia, and suprapubic pain. It has antimuscarinic and anticholinergic effects and should be avoided in patients with symptoms of gastrointestinal obstruction.

Flavoxate (Urispas) Uses:

• It is indicated for the symptomatic treatment of patients with lower urinary tract symptoms such as dysuria, urgency, frequency, nocturia, suprapubic pain, urinary incontinence in patients with cystitis, urethritis, prostatitis, urethrotrigonitis, and urethrocystitis.

Flavoxate (Urispas) Dose in Adults

Flavoxate (Urispas) Dose in the treatment of Urinary spasms:

• 100-200 mg orally thrice or four times a day.
• The dose may be reduced when the symptoms of the patient improve.

Dose in Children:

Refer to adults dosing.

Pregnancy Risk Factor B

• Negative drug reactions have not been detected in animal reproduction studies.

Flavoxate use during breastfeeding:

• It is unknown if the drug will be excreted into breastmilk.
• The manufacturer suggests that breastfeeding mothers use the drug with caution.

Dose in Kidney Disease:

Adjustment in the dose has not been provided in the manufacturer's labeling.

Dose in Liver disease:

Adjustment in the dose has not been provided in the manufacturer's labeling.

Side effects of Flavoxate (Urispas):

• Cardiovascular:

  • Palpitations
  • Tachycardia

• Central Nervous System:

  • Confusion (Especially In The Elderly)
  • Drowsiness
  • Headache
  • Hyperpyrexia
  • Nervousness
  • Vertigo

• Dermatologic:

  • Rash
  • Urticaria

• Gastrointestinal:

  • Nausea
  • Vomiting
  • Xerostomia

• Genitourinary:

  • Dysuria

• Hematologic:

  • Eosinophilia
  • Leukopenia

• Ocular:

  • Blurred Vision
  • Intraocular Pressure Increased
  • Ocular Accommodation Disorder

Contraindications to Flavoxate (Urispas):

• Pyloric or duodenal obstruction
• gastrointestinal bleeding
• obstructive intestinal lesions
• ileus
• Achalasia
• BPH is an example of an obstructive urinary tract disease.

Warnings and precautions

• CNS effects

  • It can cause blurred vision and drowsiness that could lead to impairment of mental and physical abilities.
  • Patients should be aware that some tasks, such as operating heavy machinery or driving, require mental and/or physical alertness.

• Glaucoma:

  • Patients with glaucoma confirmed or suspected should be cautious when using the drug.

Flavoxate: Drug Interaction

Note: Drug Interaction Categories:

• Risk Factor C: Monitor When Using Combination
• Risk Factor D: Consider Treatment Modification
• Risk Factor X: Avoid Concomitant Use

Monitoring parameters:

• Monitor input and output
• Observe for the signs and symptoms of anticholinergic effects.

How to administer Flavoxate (Urispas)?

It may be taken with meals to improve drug tolerability and reduce gastrointestinal side effects.

Mechanism of action of Flavoxate (Urispas):

• It is a synthetic antispasmotic drug with similar effects to propantheline. 
• It acts as a smooth muscle relaxant by inhibiting phosphodiesterase.
• It can be used to treat a wide range of smooth muscles.
• However, bladder spasms are treated with it and the urinary capacity is increased.

Onset of action:

• 55 minutes

Excretion:

• 57% of the drug is excreted in Urine within 24 hours

International Brand Names of Flavoxate:

• APO-Flavoxate
• PMS-Flavoxate
• Urispas
• Avox
• Baduson
• Bladderon
• Bladuril
• Cleanxate
• Flavate
• Flavorin
• Foxate
• Fucotin
• Genorin
• Genurin
• Genurin S
• Harnin
• Nephroflam
• Patricin
• Soolda
• Spagerin
• Spasuret
• Spasuri
• Tonlin
• U-Spa
• Urex
• Urilax
• Uripax
• Urispadol
• Urispas
• Urispas
• Urivox
• Uronid
• Uropyrine
• Uroxate
• Verispasmin
• Voxamed
• Voxate
• Yungken

Flavoxate Brand Names in Pakistan: