Kerydin (Tavaborole) is a topical antifungal agent that inhibits tRNA synthetase.

It is used for the topical treatment of onychomycosis of the toenails due to Trichophyton rubrum and Trichophyton mentagrophytes.

Treatment of fungal skin infections - a case scenario

Kerydin (Tavaborole) Dose in Adults

Kerydin (Tavaborole) Dose in the treatment of Onychomycosis:

• Topical:
• It is applied to affected toenail(s) once daily for 48 weeks.

Kerydin (Tavaborole) Dose in Childrens

Kerydin (Tavaborole) Dose in the treatment of Onychomycosis: Topical:

• Children ≥6 years of age and Adolescents:
  • Refer to adult dosing.

Pregnancy Risk Factor: C

• Some animal reproduction studies showed adverse events.

Tavaborole use during breastfeeding:

• It is unknown if tavaborole is found in breast milk after application.
• According to the manufacturer of the product, when deciding whether to continue or stop breastfeeding during therapy, it is important to consider the risks to infant exposure, the benefits to the mother and the benefits to the mother.

Kerydin (Tavaborole) dose in kidney disease:

• There are no dosage adjustments given in the manufacturer's labeling.
• However, dosage adjustment unlikely due to low systemic absorption.

Kerydin (Tavaborole) dose in liver disease:

• There are no dosage adjustments given in the manufacturer's labeling.
• However, dosage adjustment unlikely due to low systemic absorption.

Side Effects of Kerydin (Tavaborole):

• Dermatologic:

  • Ingrown nail

• Local:

  • Local skin exfoliation
  • Application site erythema
  • Application-site dermatitis

Contraindications to Kerydin (Tavaborole):

The manufacturer's labeling does not list any contraindications.

Warnings and precautions

• Local irritation

  • It can lead to persistent local irritation, erythema or exfoliation.
  • If the problem persists, instruct the patient's health care provider to take action.

Monitor:

None required

How to administer Kerydin (Tavaborole)?

• Affected toenails should be clean and dry.
• It should be applied to completely cover the affected toenail surface using the provided dropper
• Also, apply under the tip of each affected toenail.
• Avoid contact with skin other than the skin surrounding the treated toenails
• Also, wipe away excess solutions from surrounding skin and allow the solution to dry.
• Wash hands with soap and water after application.

Mechanism of action of Tavaborole (Kerydin):

• Tavaborole, an oxaborole-based antifungal medicine, inhibits fungal protein synthesis through inhibition of an aminoacyl transfer ribonucleic acids (tRNA), synthetase.

Metabolism:

• Extensive

Excretion:

• Urine

International Brands of Tavaborole:

• Kerydin

Tavaborole Brand Names in Pakistan:

It is not available in Pakistan.