Netarsudil (Rhopressa) is a rho-kinase inhibitor that increases aqueous outflow. It is used as an ophthalmic solution to reduce intraocular pressure.

Netarsudil (Rhopressa) Uses:

• Elevated intraocular pressure (IOP):

  • It is indicated to reduce elevated intraocular pressure in patients with ocular hypertension and open-angle glaucoma.

Netarsudil (Rhopressa) Dose in Adults

Netarsudil (Rhopressa) Dose in the treatment of Elevated intraocular pressure:

• Ophthalmic:
  • Instill one drop into the affected eye once a day in the evening.
  • Maximum dose: One drop into the affected eye once a day.

Netarsudil (Rhopressa) Use in Children:

Not indicated.

Netarsudil Pregnancy Risk Category: N (not assigned)

• There are no adverse effects for fetuses after ophthalmic treatment.
• To reduce exposure to the foetus, the minimal dose is combined to punctal obstruction. This will reduce systemic exposure.

Use during breastfeeding:

• It is not known if the drug will be excreted in breastmilk.
• Manufacturers recommend that infants weigh the benefits and risks of drug and therapy exposure.

Rhopressa Dose in Kidney Disease:

• The manufacturer has not listed any dose adjustment in kidney disease.
• Dose adjustment is not required because of very low systemic absorption.

Rhopressa Dose in Liver disease:

• The manufacturer has not listed any dose adjustment in liver disease.
• Dose adjustment is not required because of very low systemic absorption.

Common Side Effects of Netarsudil (Rhopressa):

• Local:

  • Application Site Pain

• Ophthalmic:

  • Conjunctival Hyperemia
  • Conjunctival Hemorrhage
  • Corneal Deposits

Less Common Side Effects of Netarsudil (Rhopressa):

• Dermatologic:

  • Erythema Of Eyelid

• Local:

  • Application Site Erythema

• Ophthalmic:

  • Blurred Vision
  • Corneal Staining
  • Decreased Visual Acuity
  • Increased Lacrimation

Contraindications to Netarsudil (Rhopressa):

The manufacturer has not listed any contraindications.

Warnings & Precautions

• Bacterial Keratitis

  • Infections of the eye can result from contamination of the product (bacterial keratitis).

Monitoring parameters:

Monitor Intraocular pressure

How to administer Netarsudil (Rhopressa)?

• It is intended for ophthalmic use only. It may be used with other medications to reduce intraocular pressure.
• When used with other eye drops, it should be instilled at an interval of at least five minutes between the medications.
• Avoid touching the tip of the dropper with fingers, other surfaces, eyes, eyelids, or the surrounding areas to minimize contamination of the product.
• Before instilling the drops, remove contact lenses. Wait for at least 15 minutes before reinserting the lenses.

Mechanism of action of Netarsudil (Rhopressa):

• Netarsudil is an inhibitor of Rho-kinase. 
• It can reduce intraocular pressure, and increase the flow rate of aqueous humor through trabecular meshwork. It is not known what the drug does.

Metabolism:

• It is converted by esterases in your eye to the active metabolite AR-13503.

International Brands of Netarsudil:

• Rhopressa

Netarsudil Brand Names in Pakistan:

No Brands Available in Pakistan.