Pramoxine is a local anesthetic that is used for the symptomatic relief of pain, burning, and stinging associated with minor skin conditions and hemorrhoids.
Pramoxine Uses:
- It is used for the temporary relief of pain and itching associated with piles, burns, minor cuts, scrapes, or minor skin irritations.
Pramoxine dose in Adults:
Dose in the treatment of minor skin irritation:
- Lotion, cream:
- Apply to the affected area up to three or four times a day.
Dose in the treatment of Hemorrhoidal itching:
- Foam, ointment, wipes:
- Apply to the affected area up to five times a day.
Use in Children:
Refer to adults dosing.
Use in pregnancy and lactation:
It has not been assigned a specific pregnancy category. Its use in human or animal pregnancy is not known. You should only use it if the benefits outweigh any risks.
Dose in Kidney disease:
No dosage adjustments have been mentioned. It may be used topically in patients with kidney disease.
Dose in liver disease:
No dosage adjustments have been mentioned. It may be used topically in patients with liver disease.
Side effects of Pramoxine:
- Local redness and erythema.
- Patients allergic to the drug may develop paradoxical pain, itching, redness, and stinging at the site.
- Dryness may occur at the site.
Contraindications and warnings:
No contraindications have been mentioned in the labeling. However, patients allergic to the drug should avoid using it.
Pramoxine: Drug Interaction
|
Methemoglobinemia Associated Agents |
May enhance the adverse/toxic effect of Local Anesthetics. Specifically, the risk for methemoglobinemia may be increased. |
Monitoring Parameters:
None mentioned.
How to administer Pramoxine?
Cream:
- Avoid applying the cream into or around the eyes.
Lotion:
- Apply the cream sparingly and use the minimal effective dose.
Foam:
- The foam should be shaken well before using it. It should be dispensed into a clean tissue and applied externally avoiding inserting it into the rectum.
Ointment:
- The ointment should not be inserted into the rectum.
Wipes:
- The area should be cleaned and rinsed before using the wipes. The perianal area should be gently patted with the wipes and discarded.
Mechanism of action of Pramoxine:
- It is a local anesthetic that relieves pain and pruritis.
- It reduces intracellular sodium influx, which results in the propagation and inhibition of neuronal impulses.
The beginning of action:
- 3-5 minutes
International Brand Names of Pramoxine:
- Calaclear
- Caladryl Clear
- Callergy Clear
- CeraVe Itch Relief
- Itch-X
- Ivy Wash Poison Ivy Cleanser
- PrameGel
- Pramox
- Prax
- Proctofoam
- Sarna Sensitive
- Anugesic
- Nestosyl
- Pramax Cream
- Primoly Gel
- Tronolane
- Tronotene
- Tronothane
Pramoxine Brand Names in Pakistan:
Tronolane cream (Abbott)
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