Topical terbinafine cream (Lamisil cream) is available both as OTC medicine and as a prescription product for the treatment of fungal infections of the skin. Note: For extensive lesions, oral terbinafine tablets should be used.

• Dermatologic fungal infections:

  • It is used in the treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm)

  • It is used in the treatment of dermatologic fungal skin infections (including tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis, and tinea versicolor) in adults.

Topical Terbinafine cream dose in Adults

OTC labeling:

• Dosage in the treatment of Tinea pedis:

  • Cream:
    • It is applied between the toes to the affected area twice daily for at least 7 days
    • apply on the bottom or sides of feet twice daily for 14 days
  • Gel:
    • Apply to affected area once daily at bedtime for at least 7 days
  • Spray:
    • Apply to affected area once daily for at least 7 days

• Dosage in the treatment of Tinea corporis, Tinea cruris:

  • Cream:
    • Apply to affected area once daily for 7 days
  • Gel:
    • Apply to affected area once daily for 7 days
  • Spray:
    • Apply to affected area once daily for 7 days

• ---

  Dosage in the treatment of Tinea pedis, Tinea corporis, and Tinea cruris:

  • Topical: Cream, Spray:
    • Apply to the affected area(s) once daily for at least 7 days

• Dose in the treatment of Cutaneous candidiasis:

  • Topical: Cream:
    • Apply to affected area once or twice daily for 7-14 days

• ---

  Dose in the treatment of Tinea versicolor:

  • Cream:
    • Apply to affected area once or twice daily for 7-14 days
  • Spray:
    • Apply to the affected area twice daily for 7 days

Topical Terbinafine cream dose in Childrens

Terbinafine dosage in the treatment of Pityriasis (tinea) Versicolor:

• Children ≥12 years and Adolescents:
  • Topical: Solution (spray):
  • Apply to affected area once daily for 7 days

Terbinafine dose in the treatment of Tinea corporis (ringworm):

• Children ≥12 years and Adolescents:
  • Topical: Cream, gel:
  • Apply to affected area once daily for at least 7 days

Dose in the treatment of Tinea cruris (jock itch):

• Children ≥12 years and Adolescents:

  • Topical: Cream, gel, solution (spray):

  • Apply to affected area once daily for at least 7 days

Dose in the treatment of Tinea pedis (athlete’s foot):

• Children ≥12 years and Adolescents:

•  Topical:

  • Cream:
    • Apply between the toes to the affected area twice daily for at least 7 days
    • apply on the bottom or sides of feet twice daily for 14 days
  • Gel:
    • Apply to affected area once daily at bedtime for at least 7 days

Terbinafine pregnancy risk category: B

• After topical application, systemic absorption is reduced.
• Topical therapy can be used if antifungal treatment is not possible to delay until after pregnancy.

Terbinafine use during breastfeeding:

• Breast milk contains terbinafine after oral administration.
• After topical application, systemic absorption is reduced.
• Breastfeeding mothers shouldn't apply topical creams to their breasts, and infants shouldn't come in contact with treated skin.

Topical Terbinafine cream Dose in Renal Disease:

• No dose adjustment is recommended when used for topical purposes.

Topical Terbinafine cream Dose in Liver Disease:

• No dose adjustment is recommended when used for topical purposes.

Less Common Side Effects of Topical Terbinafine cream include:

• Dermatologic:

  • Burning Sensation Of Skin
  • Contact Dermatitis
  • Exfoliation Of Skin
  • Pruritus
  • Skin Irritation
  • Skin Rash
  • Stinging Of The Skin
  • Xeroderma

• Local:

  • Local Irritation

Contraindication to Terbinafine Include:

• Hypersensitivity to terbinafine and any component of the formulation

Warnings and precautions

• Local irritation
  • If irritation/sensitivity develops, stop therapy and institute appropriate alternative therapy.

Monitor:

Monitor for the resolution in symptoms.

How to apply topical terbinafine cream?

Topical:

• Wash affected the area with soap and water before using and dry completely
• wash hands after use.

Spray:

• Hold 4 to 6 inches from the skin during application.

Mechanism of action of Terbinafine:

• It is a synthetically manufactured allylamine derivative which inhibits squalene-epoxidase. This enzyme is crucial in sterol biosynthesis in yeasts.
• This causes fungal cell death and a defect in the ergosterol in the fungal cell membrane.

International Brands of Topical Terbinafine cream:

• LamISIL Advanced
• LamISIL AT Jock Itch
• LamISIL AT Spray
• LamISIL AT
• Amizil
• Antifan
• Benafin
• Binter
• Derfin
• Dermasil
• Dermifene
• Farbcil
• Farbicil
• Finex
• Fintrix
• Fungasil
• Funginix
• Fungisafe
• Fungizid
• Funide
• Futeshu
• Hifen
• Interbi
• Lamater
• Lamifen
• Lamisil
• Lamisil AT
• Lamisil Once
• Lamisilate
• Lamizyl
• Lan Meishu
• Lisim
• Medisil
• Micoset
• Micozone
• Mujonal
• Murazol
• Mycelvan
• Otenol
• Patir
• Periafin
• Ronasil Derm Gel
• Sebifin
• Skinabin
• SolvEasy Tinea
• Terafan
• Terbasil
• Terbex
• Terbicip
• Terbifin
• Terbin
• Terbinorm
• Terbisan
• Terbisil
• Terbiskin
• Terekol
• Terfex
• Terfina
• Terfine
• Terfung
• Tiersil Once

Brands of topical terbinafine cream in Pakistan: