Ure-Na (Systemic Urea) for Hyponatremia

Ure-Na is systemic urea available as an orally administered highly osmolar food item. It is used as a medical food for the management of euvolemic and hypervolemic hyponatremia. Urea is also available for topical application. Topical urea is used in the treatment of the following conditions:

Dry and rough skin
Skin cracks and fissures
Dermatitis
Psoriasis
Xerosis
Ichthyosis
Eczema
keratosis
keratoderma
Corns and calluses
Damaged, ingrown, and devitalized nails.

Ure-Na dose in Adults

Ure-Na dose in the treatment of Hyponatremia:

15 to 60 g orally once a day.

Dose in Children:

Safety and efficacy of the drug in children has not been established. It is not recommended for use in children.

Pregnancy Risk Category: D

It should be avoided in pregnant and breastfeeding mothers.

Dose in kidney disease:

The manufacturer has not listed any adjustment in the dose in patients with kidney disease.

Dose in liver disease:

The manufacturer has not listed any adjustment in the dose in patients with liver disease.

Side effects of systemic Urea (Ure-Na):

Endocrine & metabolic:
- Hypernatremia
Gastrointestinal:
- Mildly upset stomach

Contraindication to systemic Urea Include:

The manufacturer has not listed any contraindications to its use.

Monitor:

Serum sodium levels

How to administer Urea (Ure-Na)?

15 gms of the dose is mixed with 3 to 4 ounces of water or juice and taken orally.

Mechanism of action of Systemic Urea (Ure-Na):

Systemic Urea is an osmotic, diuretic that causes the kidneys to excrete water free of charge.
This results in normalization of serum salt levels.
It can also be used to correct the serum sodium levels of patients suffering from the syndrome of inappropriately antidiuretic hormonal by reducing the natriuresis.