Xylometazoline is an alpha-adrenergic agonist that causes vasoconstriction of the arterioles of the nasal mucosa and conjunctiva.

• It is used for the temporary relief in nasal and nasopharyngeal mucosal congestion in patients with allergic rhinitis.

Xylometazoline Dose in Adults

Dose in the treatment of Nasal congestion: Intranasal:

• Drops (0.1%):

  • 2 to 3 drops are applied drops in each nostril after every 8 to 10 hours

• Metered-dose spray (0.1%):

  • Single spray in each nostril after every 8 to 10 hours

• Spray (0.05%, 0.1%):

  • 1 or 2 sprays are given in each nostril after every 8 to 10 hours

Xylometazoline Dose in Children:

• Infants and children 6 months to 12 years of age:

  • 2 or 3 drops of 0.05% solution to nasal mucosa every 8 to 10 hours.
  • The dose should not be repeated for more than three times in 24 hours.

• Infants younger than age 6 months

• 1 drop of 0.05% solution in each nostril every six hours as needed under medical direction

Pregnancy Risk Factor: C

• According to the manufacturer it is not recommended for use during pregnancy.

Xylometazoline use during breastfeeding:

• It is unknown if xylometazoline excreted in breastmilk or not.
• The manufacturer recommends that nursing mothers not be given xylometazoline.

Xylometazoline dose in Renal Disease:

• No adjustment in the dose is necessary.

Xylometazoline Dose in Liver Disease:

• No adjustment in the dose is necessary.

Less Common Side Effects of Xylometazoline Include:

• Central nervous system:

  • Headache

• Gastrointestinal:

  • Nausea

• Local:

  • Application site burning

• Respiratory:

  • Dry nose
  • Nasal discomfort

Contraindication to Xylometazoline Include:

• Allergy reactions to xylometazoline and any component of the formulation
• Patients who had to have transsphenoidal hypophysectomy (or surgery that exposed the dura mater) performed by a surgeon.
• Narrow-angle glaucoma
• Rhinitis sicca
• Atrophic rhinitis

Warnings and precautions

• Rebound your nasal congestion
  • Nasal congestion can recur, or worsen, if it is prolonged or repeated.
• Cardiovascular disease
  • Patients with heart disease or hypertension should be cautious.
• Diabetes mellitus:
  • Patients with diabetes mellitus should be cautious.
• Thyroid disease:
  • Patients with thyroid disease should be cautious.
• Prostatic hyperplasia/Urinary Obstruction:
  • Patients with prostatic hyperplasia or GU obstruction should be cautious.

Xylometazoline (United States: Not available): Drug Interaction

Monitoring Parameters:

No monitoring parameters mentioned. 

How to administer Xylometazoline?

For intranasal use only.

• First, blow nose to clear nostrils before using.
• Then tilt the head slightly forward (for spray) or backward (for drops)
• Then spray solution or apply drops into the affected nostril.
• After usage of spray or drops inhale deeply.
• Tip of the container should be wiped clean after each use.
• Some products are needed to be primed before initial use.

Mechanism of action of Xylometazoline:

• It stimulates the alpha-adrenergic receptors of the conjuntiva arterioles and the nasal mucosa, causing vasoconstriction

The nasal spray begins to work:

• It causes vasoconstriction in the local area within 2 minutes

Duration of action:

• It is up to 12 hours

International Brands of Xylometazoline:

• Af-Care
• Amidrin
• Antazol
• Balkis
• Cirovin
• Colirio Azul
• Decon
• Decozal
• Ezybreth
• Fastorik N
• FLO Rapid Relief
• Galazolin
• Gelonasal
• Hidropid
• Huma-Metazol
• Hysan
• Nasan
• NasenGel ratiopharm
• NasenSpray ratiopharm
• NasenTropfen ratiopharm
• Nasoferm
• Nasolin
• Nasostop
• Nazol N
• Neusdruppels
• Novin
• Novorin
• Olynth
• Osco Xuzulex Nasal Spray
• Otrinase
• Otriven
• Otrivin
• Otrivina
• Otrivine
• Pen Ke Tong
• Rhinidine
• Rhinozol
• Senziola
• Sinuvin
• Snup Stada
• Tezoline
• Tyzine
• Xoline
• Xylo-POS
• Xylolin
• Xylomaris
• Xylomet
• Xylovit
• Xymelin
• Balminil Decongest
• Otrivin
• Alpha-Adrenergic Agonist
• Decongestant
• Imidazoline Derivative

Xylometazoline Nasal Spray in Pakistan:

• Lyzo - Alina
• Nasavin - Cibex
• Rhezole - Epla
• Xlomet - Karachi chemical
• Xolisan - Sante
• Xylomed - Mediate
• Xylonas - Geofman
• Xynosine - Zafa