Terconazole cream/ suppository

Terconazole cream/ suppository - Drug Details

Terconazole is an antifungal medicine that is administered intravaginally as a topical agent.

It is used to treat patients with vulvovaginal candidiasis (moniliasis).

Since terconazole is effective only against the genus Candida, a KOH smear or culture should be performed prior to the local use of terconazole.

Terconazole dose in the treatment of vulvovaginal Candidiasis:

Vaginal cream 0.4%:
- Insert one applicatorful intravaginally at bedtime for seven days.
Vaginal cream 0.8%:
- Insert one applicatorful intravaginally at bedtime for three days.
Vaginal suppository:
- Insert one suppository intravaginally at bedtime for three consecutive days.

Not recommended for use in children

Animal studies have shown adverse fetal events.
The CDC recommends that topical azole-antifungals be used during pregnancy for a maximum of 7 days.
The manufacturer suggests that you use it with caution, particularly during the first trimester.
The product can also weaken the latex in condoms or diaphragm.

Terconazole use during breastfeeding:

The manufacturer has not recommended any dose adjustment in patients with kidney disease.

The manufacturer has not recommended any dose adjustment in patients with liver disease.

Central Nervous System:
- Chills
- Pain
Gastrointestinal:
- Abdominal Pain
Genitourinary:
- Dysmenorrhea
- Vaginal Discomfort (Burning
- Irritation
- Or Itching)
Miscellaneous:
- Fever

Severe allergic reactions, whether to terconazole and any other component of the formulation.

Warnings and precautions

Dermatologic toxicities:
- Patients who develop toxic epidermal necrolysis (TEN) should discontinue the treatment.
- It is important to provide supportive care and monitoring regularly.
- The treatment should not be recommenced.
Hypersensitivity and anaphylaxis
- Patients suffering from anaphylaxis must stop receiving treatment and should be provided with supportive care and regular monitoring.
- Reinitiation should not be encouraged.
Reactions that are unusual:
- It should be stopped if you experience fever, chills, or flu-like symptoms.
- Reinitiation should not be encouraged.
Irritation
- If you have allergic reactions or irritation, discontinue using it.
- Restart should be discouraged

Terconazole: Drug Interaction

Risk Factor X (Avoid combination)
Progesterone	Antifungal Agents (Vaginal) may diminish the therapeutic effect of Progesterone.

None required.

Vaginal cream:
- The applicator provided by the manufacturer should be used.
- Insertion into the vagina should be as far as possible without causing discomfort.
- The applicator should be washed after each use and allowed to dry before putting it back together.
Vaginal suppository:
- Before using it, remove the foil package.
- Insert the suppository into the vagina as far as possible without causing discomfort.
- If the applicator provided is used for insertion, it should be thoroughly washed and dried before using it again.

Terconazole can be used as an antifungal agent. It is a triazole-ketal antifungal, which inhibits the fungal Cytochrome P450 enzyme.
Specifically, it inhibits the cytochrome P 450-dependent 14-alpha-demethylase that results in the accumulation of membrane disturbing 14-alpha-demethylsterols and ergosterol depletion.

Absorption: Suppository: about 70% remains in vaginal area; about 10% is absorbed systemically

Protein binding: 94.9%

Time to peak, serum: about 5 - 10 hours

Half-life elimination: 6.4 - 8.5 hours

Excretion: Suppository: Urine (3% - 10%); feces (2% - 6%)